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Biotech / Medical : VD's Model Portfolio & Discussion Thread -- Ignore unavailable to you. Want to Upgrade?


To: Pseudo Biologist who wrote (4280)3/9/1998 12:58:00 PM
From: squetch  Read Replies (1) | Respond to of 9719
 
PB, I am not impressed w/ Allovectin and Leuvectin either.

I found an article/interview w/ Dr. Victor McKusick, who is labeled as the founder of modern medical genetics. The article was in MIT Technology Review July 97.

Here are McKusick's comments>>Despite all the hype about gene-replacement therapy, researchers are beginning to realize that it isn't going to happen soon enough for many medical conditions. Scientists have had a difficult time designing the vectors that carry replacement genes to where they need to go, and producing genes that both persist and function at a high enough level.

If you know the steps that connect an abnormal gene to a disorder, by contrast, then you can often intervene along the way w/ appropriate drugs and essentially cure the condition<<

His three most important trends in research linking genes to human illness 1) shift from looking at cause or precise genetic defect, to the mechanism by which disease is produced 2)study into complex diseases--involving more than one gene 3) the exciting effort to compare genomes of different species.

Not earth shattering, but he knows more about it than I.(:>) Now to find the time to check the 200 LGND posts from this weekend. squetch



To: Pseudo Biologist who wrote (4280)3/9/1998 1:27:00 PM
From: scaram(o)uche  Read Replies (1) | Respond to of 9719
 
PB:

Patient-specific therapies have always bombed. However, I am intrigued by the recent Stanford (Levy)/Vical license for anti-id in B lymphoma (similar to the early projects that almost took Idec down the drain). Note, also, that Levy's lab is doing the most advanced work with adjuvancy for DNA vaccines.

Your brief analysis nails Vical..... very accurate and, IMO, insightful. There's plenty of time left for a decision.

Rick