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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: RXGOLF who wrote (17133)	3/10/1998 11:37:00 PM
From: Abuckatatime	Read Replies (1) \| Respond to of 32384

Panretin (9-cis RA) and small cell lung CA ncbi.nlm.nih.gov Biochem Biophys Res Commun 1998 Jan 14;242(2):369-375 Effects of retinoic acid (all-trans and 9-cis) on tumor progression in small-cell lung carcinoma. Guzey M, Demirpence E, Criss W, DeLuca HF TUBITAK-MAM, Research Institute for Genetic Engineering and Biotechnology, Gebze, Turkey. meral@nucleus.mamgen.tubitak.gov.tr The two stereoisomers of retinoic acid (RA), all-trans and 9-cis-RA, are regulators of cell proliferation, differentiation and apoptosis. In this study, the aim was to evaluate the effects of all-trans-and 9-cis-RA on cell growth, proliferation, and on the induction of apoptosis in the human small cell lung carcinoma (SCLC) cell lines NCI-H82 and NCI-H209. The application of various concentrations of all-trans and 9-cis-RA were able to inhibit cell growth and proliferation. Moreover, 3H-thymidine incorporation was inhibited and the number of viable cells decreased, suggesting that all-trans-RA and 9-cis-RA can inhibit cell proliferation in a dose dependent manner. Morphological examinations (light, electron and fluorescence microscopy) demonstrated that both retinoids had profound effects on the induction of apoptosis. Our investigation also showed that, compared to all-trans-RA, 9-cis-RA is a stronger inducer for the inhibition of cell growth and proliferation and that it is more effective in the induction of apoptosis in small cell lung carcinoma cells in culture. PMID: 9446801, UI: 98113359