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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: RT who wrote (5870)	3/11/1998 10:10:00 AM
From: g.w. barnard	Read Replies (2) \| Respond to of 23519

has anyone posted this from aol board: in correspondence bigkny3. if this data is correct it would seem very harmful to viagra claims??? gw This is from pfe documentation which has been send to me by pfizer in regards to viagra: Abstracted Presented at the 1997 American Urological Association Ninety-second Annual Meeting:Documentation # 701 J Urology 1997;157(4);181 (Presented by Dr. Lue) <<416 patients from 22 sites were randomly allocated to receive placebo, 5,25,50,or 100 mg of sidenafil by self-adminstrated questionaire (IIEF) at week 8. A global assessment question (GAQ) was asked at week 8 (Did treatment improve your erection?). Specifically the IIEF addressed the ability to achieve (Q3) andmaintain (Q4) an erection satisfactory for sexual intercourse, with responses graded on a scale from 1 (almost never or never) to 5 (almost always or always). Safety and toleration were evaluated by routine labratory texts and recording of adverse events (AEs), RESULTS:* Sidenafil ---------------------------------------------------- Question Placebo 5mg 25 mg 50 mg 100mg GAQ (%yes) 27.7 47.7 60.9 72.9 77.8 Q3 (mean) 2.00 2.69 2.93 3.28 3.69 Q4 (mean) 2.05 2.40 2.95 3.32 3.60 p-value < 0.0001 by ANOVA; * Mean response scores Responses to other IIEF questions showes similar dose-response relationships for other aspects of erectile and sexual functioning. The most common AEs were headache (2.4-11%), vasodialation 0-8.5%), dyspepsia (0-8.5%), and Diarrhea (0-4.9%), which were predominantlyof mild severity.>> So now lets analyse above: 1- from 416 patients after 8 weeks using the pill, 95 patients never had any improvements in their erection at all during whole usage of the pill within 8 weeks... 2- Only a mean of 3.69 among 321 had ability to achieve erection during 8 weeks usage of the pill... 3- It reveals no one or a few among the whole patients during the whole 8 weeks had achieved an erection for satisfactory intercourse... imo, the study reveals very negative aspects regarding the effectiveness of sidenafil (viagra)... PS Docment #702 of pfe mailed to me reveals viagra by itself is not effective for SCI patients, a viberator has to be included...what is that all about? I will post that in later time....

To: RT who wrote (5870)	3/11/1998 12:25:00 PM
From: Chris Delap	Read Replies (1) \| Respond to of 23519

RT, Depending on the method of payment the patient may be limited on getting more than on package at a time. Most HMO's limit how much you can get a once (frequently a months supply, how many packs is that?). It also depends on the prescription, if the doctor says no refills then they can only get one pack. TA can answer to what is SOP for refills on this type of drug. Chris

To: RT who wrote (5870)	3/11/1998 7:49:00 PM
From: Edderd	Read Replies (1) \| Respond to of 23519

RT, There may be several real reasons for the decrease in demand. Dosing the patient is very important and initially the patient needs some instruction in the use of the pellet and inserter. Our satisfaction rate is much higher in those patients we have instructed in the office than those who just watch the video ( at home) and try it. The effect of Viagra and the incredible PR they have received is taking a toll of some patients who want to wait for the pill. Interestingly I think (IMO) that many of these patients will be failures with Viagra as they seem not to be well motivated but looking for the no-effort solution. Our experience is not a real shortage at this time but the availability seems to be localized to a few Pharmacies that are willing to break up the six packs for our patients. I'm sure that in smaller communities the shortage is probably very real. Ed