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To: Christopher Clark who wrote (5638)	3/13/1998 3:21:00 PM
From: Dave Newsom	Read Replies (1) \| Respond to of 9569

Chris - Thanks for being there you have enabled us all to benefit. You really benefited from being there and probably got a feel for the company better than we who could not attend. Those small fact to face conversations etc I know provide a wealth of information that can't always be expressed. Thanks again

To: Christopher Clark who wrote (5638)	3/13/1998 3:39:00 PM
From: Carol Putnam	Read Replies (2) \| Respond to of 9569

Thank you for scanning in the brochures and kit information. Must say, I have never seen a business card printed on the vertical rather than the horizontal! I wanted to take advantage of this opportunity to post this interesting article for all to read. This is no small problem: <Picture: Business Wire > <Picture: [Datek]> [ Business \| US Market \| Industry \| IPO \| S&P \| International \| PRNews \| BizWire \| Finance Home ] ------------------------------------------------------------------------ Monday March 9, 9:01 am Eastern Time Company Press Release Temperate Regions Global Warming Would Foster Spread of Dengue Fever into Some BALTIMORE, Md.--(BUSINESS WIRE)--March 9, 1998--Scientists using computers to simulate the general circulation of the earth's climate have predicted that rising global temperatures will increase the potential transmission of the dengue fever virus. Dengue fever is now considered the most widespread viral infection transmitted in man by insects, whether measured in terms of the number of human infections or the number of deaths. Their report appeared in the March 1998 issue of Environmental Health Perspectives, the monthly journal of the National Institute of Environmental Health Sciences. Most of the new areas of increased potential risk were predicted to be temperate regions that currently border on endemic zones. These fringe areas represent places where humans and the primary carrier, the mosquito Aedes aegypti, often co-exist, but where lower temperatures now limit disease transmission. Lead author Jonathan Patz, MD, MPH, from the Johns Hopkins School of Public Health said, ''Since inhabitants of these border regions would lack immunity from past exposures, dengue fever transmission among these new populations could be extensive.'' Unlike the yellow fever virus, carried by the same mosquito, the dengue virus is not vulnerable to any vaccine or drug. Major epidemics of dengue have occurred in the southeast United States, the largest in Galveston, Texas, in 1922, when over 500,000 people were stricken. The last outbreak in Texas occurred as recently as 1995, during an unseasonably hot year. The researchers used three different general circulation models to predict the patterns of global climate change; all three showed that dengue's epidemic potential increases with a relatively small temperature rise. The higher a virus's epidemic potential, the fewer mosquitoes are necessary to maintain or spread dengue in a vulnerable population. The geographic range of Ae. aegypti is limited by freezing temperatures that kill overwintering larvae and eggs, so that dengue virus transmission is limited to tropical and subtropical regions. Global warming COULD increase the range of the mosquito. In addition, the time the virus must spend incubating inside the mosquito is shortened at higher temperatures. An estimated 2.5 billion people are currently at risk from dengue infection, and since the late 1970s dengue has reemerged in the Americas. In 1997, 240,587 cases of dengue were reported in Brazil alone, according to the ministry of health. This past January, responding to weather generated by El Nino, dengue transmission rates in southeastern Brazil increased nearly six-fold from 1997 levels. Outbreaks in urban areas infested with Ae. Aegypti, can be explosive, involving up to 70-80% of a population. While the accuracy of long-term climate forecasting by computers will continue to be questioned, the global warming scenarios predicted by the various different computer models are increasingly coming to resemble one another. Climatologists are projecting that global climate will change at an unprecedented rate over the next century. Dr. Patz said, ''Our study makes no claim that climate factors are the most important determinants of dengue fever. However, our computer models illustrate that climate change may have a substantial global impact on the spread of dengue fever.'' The study was funded in part by the Climate Policy and Assessment Division of the U.S. Environmental Protection Agency, the National Institute of Public Health and Environment (RIVM) (The Netherlands), and the Center for Medical, Agricultural, and Veterinary Entomology of the U.S. Department of Agriculture. ------------------------------------------------------------------------ Contact: Hopkins School of Public Health Sharon Rippey or Michelle Parker, 410/955-6878 E-mail: paffairs.@jhsph.edu ------------------------------------------------------------------------ Related News Categories: environmental, medical/pharmaceutical ------------------------------------------------------------------------ Help ------------------------------------------------------------------------ Copyright c 1998 Business Wire. All rights reserved. All the news releases provided by Business Wire are copyrighted. 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