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To: Edderd who wrote (5913)	3/16/1998 7:48:00 PM
From: Edderd	Read Replies (1) \| Respond to of 23519

0022-534W98/1594-1214$03.OOlO THE JOURNAL OF UROLOOY Vol.159, 1214-1216, April Copyright c 1998 by AM~RIcAN UROLOGICAL ASSOCIATION, INC. Printed in l ORAL PHENTOLAMINE AS TREATMENT FOR ERECTILE DYSFUNCTION ARMJN J. BECKER, CHRJSTIAN G. STIEF*, STEP HAN MACHTENS, DIRK SCHULTHEISS, UWE HARTMANN, MICHAEL C. TRUSS ANI) UDO JONAS From the Departrneots of Urology and Clinical Psychology, Medizinsche Hochschule Hannover, Hannover, Germany ABSTRACT Purpose: For most patients with erectile dysfunction oral agents are a preferred treatment option. Oral or buccal phentolamine has been shown to produce full erections in impotent subsets of study populations. We evaluate the efficacy of oral phentolamine. Materials and Methods: After a comprehensive evaluation 44 patients with recent onset (less than 3 years) of erectile dysfunction and a high likelihood of organogenic etiology underwent a prospective, double-blind and placebo controlled trial with oral phentolamine after placebo. Results: After placebo 4 of the 44 patients who reported full erections were excluded from study. Of the 40 patients in the double-blind phase full erections were achieved by 2 of 10 with placebo, and 3 of 10 with 20 rng., 5 of 10 with 40 mg. and 4 of 10 with 60 mg. phentolamine. There were no serious complications observed during the study, and only a single minor side effect occurred in 1 patient after 60 mg. phentolamine. Conclusions: Our results indicate that oral phentolamine may be of benefit for the treatment of erectile dysfunction. Further studies are required to corroborate our findings. KEY WORDS: penile erection, phentolamine Here is the abstract on Phentolamine Ed