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Biotech / Medical : IMNR - Immune Response -- Ignore unavailable to you. Want to Upgrade?

To: Steve Lokness who wrote (349)	4/4/1998 10:11:00 AM
From: Easy Mark	Read Replies (1) \| Respond to of 1510

I was avoiding saying that CEGE's approach is flawed because I do not know. Could you post CEGE's explanation of how they recognize mutates? Prior approaches based on gp120 have failed because HIV mutates the outer protein envelope to avoid recognition. It seems to me possible that CEGE's positive results could simply be due to inserting a massive dose of virus killers into patients for whom the t-cells have been deficient. If this is the case then the drug cocktails are probably more efficient virus killers, although there might be an issue with side effects. Its also possible that they are making further genetic modifications so it recognizes other proteins. Another issue that I wonder about is why does it make sense to manufacture t-cells outside the body when the body is perfectly capable of manufacturing its own when stimulated to do do - which is what Remune does. CEGE's approach seems like it would be awfully expensive. They need to take each patient's t-cells and genetically modify a batch of their t-cells. I believe the nature of t-cells is such that each patient is unique. I haven't seen cost estimates - has anyone else? The argument that both approaches suffer from, from the perspective of their detractors, is that the body is already presented with a huge stimulus by virtue of the HIV infection. Remune's answer is that the body's immune system will not attack the infected t-cells, but can be stimulated to do so. What is CEGE's answer?