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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?


To: mc who wrote (3439)4/18/1998 2:50:00 PM
From: Dauntless  Read Replies (1) | Respond to of 7041
 
Gary - OTOTOT - Really? Tell me who posted these....

If you're not interested in the TUNA discussion, skip the rest of this - there are several TA posts pasted in here.

Here are a few posts, in chronological order from "TA". Most of them were part of a generally negative running commentary on Zonagen. I've left some out in between, mostly because they are too long. I could get several off the Vivus thread as well. You claim the son posted these? You claim it's "obvious"? How???

More importantly, assuming the father is an MD - he posts some messages convincing people of his credentials - then junior gets on and offers investment advice with the same ID. You don't see anything wrong with this??
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To: +Keith Rubin, MD (1897 )
From: +Tunica Albuginea Wednesday, Jan 21 1998 2:05PM ET
Reply # of 3439

All right Keith, ( can I cal you Keith? fell free to call me TA, gg ).
I will skip the general medical exam ( so we won't bore the audience, gg, and save time ) and try and achieve the same in a round about
fashion: Here are the questions:( first of medical natue, and then investing type).

A 65 yo W/M takes 1 Vasomax pill for ED.He is 6 ft 2 inches and is overweight at 250 lbs. Please show me the exact calculations you would use, and the results, to tell me:
- what is his total body water?
-what is his ideal body weight?
-how many liters of fluid are in his intravascular compartment and
how many in his interstitial compartment?
-what will the final concentration of phentolamine be in his serum
at 1/4, 1/2, 1 , 2, and 3 hours after ingestion.
-what is the final concentration be in the corpus cavernosum?
-what will the drop in his Blood Pressure ( systolic, diastolic,
lying and standing (are there +orthostatics ?)
be at the time his penile artery is vasodilated? )
-what is the t 1/2 of serum phentolamine?
------------------------------------------------------------------
Investment questions: why are we hearing just now of a buccal admininstration of Vasomax and not before?
-Mucosaly absorbed vasodilators are fairly dfangerous because of the " rush" of drug in your system: that is why Pfizer's subling Procardia has been taken off. How is Phentolam different than Procardia? You are talking about an effect within 10-20 min.
Thanx

TA
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To: +Linda Kaplan (2001 )
From: +Tunica Albuginea Friday, Jan 23 1998 5:20PM ET
Reply # of 3439

All right Linda, in deference of your long standing loyalty to MUSE
I will lay off the testing business. However I would still like to reserve thr right to judge medical competence. Not infrequently that can come about in other ways.

TA
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To: +Dr. Voodoo (1999 )
From: +Tunica Albuginea Friday, Jan 23 1998 6:39PM ET
Reply # of 3439

Voodoo, this paper dated 1976.I believe I saw a reference to it in a textbook of cardiology published few years ago where they mentioned using phentolaamine pills for blood pressure therapy but gave it up because of side effects . I think the Editor was a Dr Parmley. I'll try and get the source if I have time.

TA
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To: +Dauntless (2090 )
From: +Tunica Albuginea Thursday, Jan 29 1998 4:28AM ET
Reply # of 3439

Clueless: I would not touch this dog if you paid me in gold dobloons.
Re: " creates wonderful buying opportunities for knowledgeable investors."
Should read instead: "It creates wonderful buying opportunities for ignorant suckers ">

TA
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To: +Dr. Voodoo (2091 )
From: +Tunica Albuginea Thursday, Jan 29 1998 4:33AM ET
Reply # of 3439

DrVoovdoo, take a clue for heaven's sake : " I think this drug is pretty well studied. ~9000 references available with my search engine. ".

"-I'm to lazy to look further back, that's real work).".

Doctor, do yourself a favor; drop this dog and go home and get some rest. You've researched- the dog - over and beyond the call of duty.

TA
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To: +Bill Wexler (2153 )
From: +Tunica Albuginea Saturday, Jan 31 1998 1:25PM ET
Reply # of 3439

Bill, as a physician,I must concur 100% with your post. I have no idea how Dr Rubin, after opening up the American Hospital Formulary Service Drug compendium on all his hospital floors,all the Crdiology and Pharmacology textbooks published the last 15 years and reading them( as he should, as an alleged Internist) about phentolamine, can still go out long on this company in the ABSENCE of ANY MENINGFULL SCIENTIFIC DATA.
Such a wonderfull world............
TA
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To: +Gary McBride (2342 )
From: +Tunica Albuginea Friday, Feb 13 1998 2:36PM ET
Reply # of 3439

Gary, I leave for a few days and when I get back I find the same thing: stock manipulation, and hype. Meanwhile everything there is to know about phentolamine can be accessed by walking though ANY US hospital and asking your friendly nurse at the desk if you can just look up the 1997 edition of AHFS ( Amer Hosp Formulary Services )
book, the " Golden Standards " book published by the Who's Who in the US Pharmacology Universities. 30+ years of research on phentolamine /Vasomax, for free, by the No1, 2, 3, 4, 5, 6 etc researchers in the US. Then figure out if this is something a prospective US ED patient is likely to put in his mouth.
I believe that simple exercise will save investors countless hours of rhetoric in this thread by Clueless and company, all IMHO.

TA
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Gary - back to today & your post -

Zonagen is not filing the NDA, SGP is - and the tail rarely wags the dog. Zonagen did predict one filing date and missed it - I don't think you'll it missed again by SGP. The official line is - in the first half of 1998.

If I seem uptight to you don't worry about it - I sleep very well. Curiously, I never picked up the sword to defend the stock price - just to keep the outright liars - Asensio & his gang - from having the whole forum to themselves. To the best of my recollection, I have never suggested that anyone buy this stock. I'm only interested in seeing it fairly evaluated on honest facts. Guarding the truth sometimes gets messy around here - but I love it. When the NDA is filed and the lawyers realize that Asensio's reports are totally flawed and therefore drop the lawsuits, I'll probably just relax and wait for the FDA's decision.