To: David Lawrence who wrote (14940 ) 4/22/1998 1:18:00 AM From: Scrapps Read Replies (1) | Respond to of 22053
[More T/A] Life is a day at the beach for clams on Prozac GETTYSBURG, Pa. (Reuters) - Prozac, the mood-altering drug used to control depression in people, also can play a productive role in the lives of clams and mussels by getting them in the mood to spawn, a biologist said Thursday. Research by Gettysburg College biology professor Peter Fong shows that the widely prescribed anti-depressant stimulates spawning in freshwater fingernail clams and zebra mussels. Rarely has either animal been observed to spawn in the wild or in the laboratory without the use of an artificial chemical aid. "A little bit of Prozac goes a long way," Fong said in an interview. His research suggests that Prozac acts on mollusks in the same way it affects human beings. The drug allows both subjects to secrete more serotonin, a neurotransmitter that exists in all organisms and regulates moods in people. In the human brain, Prozac blocks an enzyme that inhibits serotonin production, enabling greater quantities of the natural chemical to be released. The drug inhibits the same proteins in mollusks. Biologists have known for some time that serotonin induces clams and mussels to spawn. But Fong's research shows Prozac to be far more effective and cheaper for aquatic farmers. Serotonin costs about $22 a gram, which can be a great expense for farmers in the developing world. Although Prozac is 190 times more expensive, Fong said, it has been proved effective at less than 0.002 the quantity of serotonin. Prozac, which is manufactured by Eli Lilly & Co. of Indianapolis, is known generically as fluoxetine. Some 22.8 million prescriptions for the drug were written last year. Fong's research was due to be published this week in the science journal Biological Bulletin.