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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: Russian Bear who wrote (19540)4/24/1998 9:48:00 AM
From: Henry Niman  Read Replies (1) | Respond to of 32384
 
Here's more on memory and hormones (cortisol acts through an IR):
Stress May Lead to Mental Decline

By HELEN PHILLIPS
c.1998 Nature News Service

It seems that our hormones, our diets, our lifestyles and our genes all
club together to wear out our bodies and wither away our mental
faculties - a process referred to as aging. When it comes to cognitive
powers, it seems we can now add stress to the list of factors that
speed up our decline.

A report in the first issue of the journal Nature Neuroscience now
finds that continually high levels of stress hormones seem to speed up
aging of the human brain and cause a decline in certain types of
learning and memory.

Alzheimer's disease and normal aging both lead to a decline in a part
of the brain linked to spatial learning and memory. The region, known
as the hippocampus (because it is shaped like a horse's head), is full of
sites where stress hormones could bind, so it seems sensible to
suggest that stress might also affect this part of the brain.

For about 20 years, it has looked as though the hippocampus of
laboratory rats with higher than normal levels of stress hormones aged
more rapidly than normal. But whether the same aging process goes
on in humans has remained hard to test and very controversial.

Now Sonia Lupien of McGill University and The Geriatric Institute of
Montreal, in Quebec, Canada, and her colleagues, have used a
brain-imaging technique, memory tests and a five-year-long study of
levels of the main stress hormone, cortisol, in normal elderly people, to
test the link between stress and brain aging.

They found that the people with the highest cortisol levels, as well as
those with the most rapidly rising levels, had the smallest hippocampal
volumes. Moreover, these people also tended to do less well on the
memory test and at solving mazes (a test of spatial abilities).

Nada Porter and Philip Landfield of the University of Kentucky seem
convinced by the findings. Discussing the work in an accompanying
commentary, they say ''Lupien and colleagues now provide
substantial evidence that long-term exposure to adrenal stress
hormones may promote hippocampal aging in normal elderly humans.''

How does cortisol cause aging? Porter and Landfield make some
suggestions. Stress hormones are designed to divert our energies to
cope with the immediate worries rather than longer-term maintenance.
Cortisol may therefore reduce the levels of the nutrient glucose, slowly
starving the cells. The hormone may also make nerves more likely to
be killed by the body's own clearing-up processes. Additionally, our
mental abilities may be slowed by the remaining cells being less active.

But before we all start worrying about getting stressed, and what it
might do to our brains, Porter and Landfield explain that the problems
are brought about by long-term exposure to stress hormones. Rapid
brain aging is not the result of normal day-to-day worries and stresses.

Long-term individual differences in cortisol levels, however, may
explain why some people's mental abilities decline faster than others as
they grow older.



To: Russian Bear who wrote (19540)4/24/1998 3:32:00 PM
From: Flagrante Delictu  Read Replies (3) | Respond to of 32384
 
RB, OFF TOPIC, Re: the academic models. The real problem ,IMO, is not so much in the models, which, by their very nature , are imperfect, but in their interpretation to others by some who really don't understand the very models they are referencing. One obvious area is the failure to notice these models were designed to facilitate decision making by those who can access "the risk free interest rate". Another area is in not understanding that the model provides a means to understand relative values & is not at all predictive of actual values. Another problem I observed in the comments of others, comparing LGND to LGNDW, was preconceived opinions on the "riskiness" of certain instruments without the understanding that the risk or lack thereof was not inherent in the instrument but arose from the price differential between the instruments being analyzed & the conditions of their relationship. For example, it appeared to me that one or more of the commentators thought warrants are always riskier than their underlying stocks. People who actually deal with these things quickly learn that such a thesis is incorrect. For example, my argument is that LGNDW at $6.125 under the stock at the time of the discussion was not more risky than the stock because interest rates of even 8% compounded monthly for the 2 years and 1 1/2 months remaining to expiration would be commensurate with, if not greater than, the $1.00 per share that the warrant holder would lose on his position relative to the stock at expiration. If he lost $1.00 here & got it back there, he had no loss & therefore would make exactly as much on the upside as the stock, but stood to lose less, possibly a lot less than the stock, all the while having to part with less out of his pocket. Yes, all but one figured out the warrants were a better buy than the stock,but posted information that was simply not true in attempting to explain the theories to the threadsters.
Even if we take your 7% interest costs on your margin account, which is probably less than most threadsters command,compound them monthly for the 25 1/2 months left to expiration at the start of the discussion, we should arrive at approximately $1.00 in interest charges saved by not having to put up the $6.125 for the 25 1/2 months.
A warrant that gains penny for penny with the stock on an upmove & can lose no more than the stock on a down move, & might possibly lose up to 40% less than the stock on a down move, & which requires a lower up front payment is clearly not riskier than it's underlying stock. Yet , we saw posts on the VD thread, claiming it was, which claims were backed up with such academic jargon as "greater leverage means greater risk by definition", "the warrant has more risk than an unlevered investment in LGND for the same reason as a margined investment has more risk", " if you are assuming you hold only as many warrants as stock, then the warrants will do worse if the stock appreciates, because of the premium you paid, which will be greater than the margin savings", "buying the warrants probably only makes sense if you are already margined to the hilt & want even more leverage","here, most, if not all the benefit (of buying the warrant & selling the stock) is wiped out by the spreads & transaction costs", "the difference (of $6.125 less than the stock) is probably not worth the transaction costs of switching from stock to warrant".
The warrant & $7.12 cents will buy one share of stock. Obviously, if you own the warrant at a price equal to $7.12 less than you would have had to pay for the stock, you will make exactly as much as the stock in an upmove, because if the warrant doesn't move up similarly, you just hand it in to LGND with$7.12 in cash & receive LGND stock, if you so choose. If you buy LGNDW for $7.12 less than the stock, by definition, the stock is riskier because it can decline $7.12 more than the warrant & not appreciate more, yet your position is leveraged with regard to the stock because you control the same upside as the stock & lower downside with a smaller cash outlay.With regard to transaction costs, some brokerage firms are actually advertising NO transaction costs. The liquidity argument against the warrants is solved by short sales of the stock against the warrant position, because the stock is not illiquid. The argument that the spread between bid & asked kills you is countered by the advice to buy the warrants only when available at the appropriate differential to the stock, which was available at the time of the discussion & is intermittently available from time to time.
Let me state for the record that all those who commented on the difference are good, intelligent, admirable people. My argument is not with them but with some items they mentioned which do not comport with the reality that I have observed as a practitioner of the arts they discuss.
Best regards & let's try to find a blackjack emporium whose integrity we can trust, which still offers single deck blackjack with Vegas rules. I'll bring a sack into which we can pour the winnings.