To: scaram(o)uche who wrote (177 ) 4/24/1998 5:10:00 PM From: scaram(o)uche Respond to of 579
Mike: I don't have time to check now, but I don't think that this chunk of shares can account for the total slug that was traded. Filing of April 20, 1998, stake up to 10.4%. Guess it's no longer a rumor........ Since February 20, 1998, Partners, in its capacity as general partner of BVF, has purchased on behalf of such limited partnership an aggregate number of 152,500 shares of the Stock for an aggregate consideration of $763,480, utilizing funds provided by BVF from its working capital pursuant to the terms of its limited partnership agreement with Partners. In addition, Partners, in its capacity as investment manager with respect to certain managed accounts, has purchased on behalf of such managed accounts an aggregate number of 271,000 shares of the Stock for an aggregate consideration of $1,357,984.90, utilizing funds under management by Partners pursuant to investment management agreements between Partners and such managed accounts. TYPE: EX-99.B SEQUENCE: 3 DESCRIPTION: TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS EXHIBIT B TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS -------------------------------------------------- DURING THE PAST SIXTY DAYS -------------------------- -------------------------------------------------------------------------------------- Settlement By For the Quantity Price Type of Trade Broker Date ----------- Account of -------- per ------------- ------ ---------- ----------- Share --------- -------------------------------------------------------------------------------------- 03/24/98 BVF Ltd. Partners 3,000 $5.3333 Purchase INET -------------------------------------------------------------------------------------- 03/25/98 BVF Ltd. Partners 4,000 $5.2500 Purchase INET -------------------------------------------------------------------------------------- 04/03/98 BVF Partners 3,500 $5.2500 Purchase INET -------------------------------------------------------------------------------------- 04/03/98 BVF Ltd. Partners 3,000 $5.2500 Purchase INET -------------------------------------------------------------------------------------- 04/20/98 BVF Partners 149,000 $5.0000 Purchase VECT -------------------------------------------------------------------------------------- 04/20/98 PAL Partners 40,000 $5.0000 Purchase VECT -------------------------------------------------------------------------------------- 04/20/98 ZPG Partners 27,000 $5.0000 Purchase VECT -------------------------------------------------------------------------------------- 04/20/98 BVF Ltd. Partners 194,000 $5.0000 Purchase VECT -------------------------------------------------------------------------------------- INET = Instinet VECT = Vector Securities