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Biotech / Medical : Vivus: into single digits -- Ignore unavailable to you. Want to Upgrade?

To: Colby who wrote (405)	4/28/1998 3:21:00 PM
From: BDR	Read Replies (1) \| Respond to of 1016

< It would be interesting to know at what levels the headaches became so severe.I got the impression they started at lower doses (that being relative, say 100mg) and increased from there. >> I believe the number is 16% of the men using the drug in the approved range of 25mg-100mg reported headaches. I understand higher doses = higher rates, perhaps more severe. <<Is it me, or do these stories lack consistency?>> Well PFE can only say in its materials what the FDA approves. Time will say whatever sells the magazine. (Time sensationalizes the news? No!) <<In regards to taking with other meds, I know nitro isn't the only one we want to avoid contact with. How do drugs commonly taken by elderly people mix with Viagra?>> So far Tagamet (Cimetidine, for heartburn/ulcers), Erythromycin (an antibiotic), and ketoconazole (an anti-fungal) have been shown to increase the blood levels of Viagra when taken concurrently. One might take Tagamet chronically, ketoconazole for several weeks to months and Erythromycin for one to two weeks. The solution would be to not take Viagra while you are on the other drug or to reduce the dosage. Apparently no deleterious effects except for increased side effects. Nitro has potentially severe side effect (30-40 point drop in blood pressure noted during the trials, I am told) and could be lethal. It is an absolute contraindication to the use of Viagra. <<Out of curiousity, what is the average age of people you treat for ED?>> Not sure, but probably early sixties.