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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Hank who wrote (3792)	5/2/1998 12:35:00 AM
From: Linda Kaplan	Respond to of 7041

Yup, the studies have been completed for a long time now. I wonder what kind of massages are being given to that data for all this time, don't you? Given that these figures have been published in numerous press releases, it's amazing that the CEO gave DIFFERENT figures to the WSJ than he himself has published in the press releases. Every time he speaks, the results improve. LOL! I never believed that he was pumping the stock till I saw that evidence last week. I'm still shocked by my insight that the CEO is misrepresenting the results of the stock to the Press! How can he get away with that? That's what some of the zillions of law suits against him and the company are about! It's nutty that he's doing that while under that kind of scrutiny. Hubris, I guess. David belongs here! Pseudo scientist, running around jumping to conclusions, running his mouth before he knows what he's talking about, breaching confidences. You can be sure if I posted what HE shared with ME in email he'd be whining all over the place about MY ethics. This guy can't even read the press releases but attacks me for quoting information that's been public from the company for a year. I have the poster here and he says I'm fabricating the information. Shooting from the hip is not science, Folks. This is definitely the company for David. Pseudo science, posts representing questionable ethics. It's a match. I will post the poster content tomorrow. I'm way over tired. Linda

To: Hank who wrote (3792)	5/2/1998 11:13:00 AM
From: Linda Kaplan	Read Replies (1) \| Respond to of 7041

Here's the text of the poster on Vasomax. A few characters were smudged so there may be an error in one or two characters: EFFICACY AND SAFETY OF ORAL PHENTOLAMINE (VASOMAX) FOR THE TREATMENT OF MINIMAL ERICTILE DYSFUNCTION Irwin Goldstein and the Vasomax Study Group, Boston, MA, Presented by Dr. Goldstein INTRODUCTION AND OBJECTIVES: This study reports the results of the first double-blinded, placebo-controlled studiesevaluating the efficacy and safety of oral phentalomine in the treatment of patients with minimal erectile dysfunction of broad specturm etiology. METHODS: Tso multi-center trials were conducted in the United States in men with minimal erectile dysfunction. The first was designed as a placebo controlled, parallel group, double-blind study involving randomized doses of 40 or 80 mg of oral phentolamine or placebo. The second was a placebo-controlled crossover design trial of fixed dose 40 mg oral phentolamine vs. placebo. A responder was considered any patient whose endpoint International Index of Erectile Function domain score improved by at least one clinical dysfunction class and who meets the criteria at least for mid-to-moderate dysfunction at endpoint. RESULTS: Study No. Treatment Group n %of Responders %of Non-Responders ZON 301 Placebo 148 16 84 40 mg Vasomax 152 37 63 80 mg Vasomax 159 45 55 p<0.001 (CMH, controlling for investigator) ZON 300 (first period crossover) Placebo 145 21* 79 40 mg Vasomax 148 34* 64 p<0.009 (CMH, controlling for investigator) *Includes all ITT patients with non-missing data There were no serious adverse events. Side effects to the 40 mg phentolamine(<10% occurrence)included headaches, facial flushing, nasal congestion. CONCLUSIONS: Oral phentolamine (40mg) is a safe and effective oral medication for the treatment of mild erectile dysfunction.