To: David Israel-Rosen who wrote (760 ) 5/7/1998 12:21:00 PM From: David Israel-Rosen Read Replies (1) | Respond to of 1491
Management is listening to share holders: Thursday May 7, 11:50 am Eastern Time Company Press Release SOURCE: Pharmos Corporation Pharmos Corporation Product Development Update ISELIN, N.J., May 7 /PRNewswire/ -- Pharmos Corporation (Nasdaq: PARS - news) announced that Lotemax(TM) and Alrex(TM), products co-developed and marketed by Bausch & Lomb Pharmaceuticals, Inc. (NYSE: BOL - news), will available by prescription on June 1. Pharmos Corporation recently completed enrollment of severe head trauma patients treated with the second dose (150 mg) of dexanabinol (HU-211) in its Phase II clinical trial and began enrolling patients to be treated with the third dose (300 mg). Sixty-seven patients have been enrolled so far with no apparent safety concerns (an external safety committee is monitoring the study). The overall mortality in the study is about 12%, a low percentage based on the patient population which consists of severe head trauma patients with Glasgow Coma Scores between 4 and 8. The company is planning to unblind the first two dosages (50 mg and 150 mg) this summer. The information will help with the planning of Phase III clinical trial in head trauma, Phase II in stroke, and in negotiations with strategic partners. The company is continuing the development of its tamoxifen analog program. In pre-clinical studies one analog, tamoxifen methiodide (TMI) has expressed higher tumorcidal activity compared to tamoxifen. The results may be due to TMI's mechanism of action including its anti-angiogenic activity. TMI also demonstrated a much better safety profile than the base tamoxifen used in the National Cancer Institute study. Pharmos plans to complete the pre-clinical development of this analog toward the end of 1998. Pharmos Corporation ( pharmoscorp.com ) is a pharmaceutical company specializing in the modification of existing molecules to improve their therapeutic index, i.e. reduce undesirable side effects and/or enhance efficacy. This news release contains forward-looking statements that involve risk and uncertainties. The development of the company's products may differ materially from the company's expectations. Among the factors that could result in a materially different outcome are the inherent uncertainties accompanying new product development, action of regulatory authorities and the results of further trials. SOURCE: Pharmos Corporation