To: TokyoMex who wrote (15862 ) 5/8/1998 11:25:00 AM From: Brian Gross Respond to of 34592
MEDX - Conference Monday - Phase 2 Cancer trials on humans from yahoo thread of enmd Top:Business and Finance:Stocks:Healthcare:Biotechnology & Drugs:ENMD (EntreMed, Inc.) <- Previous Next -> Message 1136 of 1152Reply MEDXSDMAN222 May 8 1998 3:19AM EDTNext 2 weeks should be interesting with this one:MDX210 moving further! PRODUCTS UNDER DEVELOPMENT Medarex has five therapeutic products currently in clinical development and several products in pre-clinical investigation. Cancer MDX-210, an anti-cancer Bispecific to treat HER-2 positive tumors, is currently in Phase II clinical studies for prostate, renal and colon cancer. Interim results of the renal and prostate cancer studies demonstrated anti-tumor activity, including measurable reductions in tumor size, pulmonary metastases and serum prostate specific antigen (PSA) levels. HER-2 is overexpressed on a significant number of tumors, including prostate, renal, colon, non-small cell lung, gastric and pancreatic cancers. MDX-210 is being developed in conjunction with Novartis, Inc. MDX-447, an anti-cancer Bispecific for tumors that express the EGF receptor, is a collaborative product with Merck KGaA. MDX-447 is currently in Phase I/II clinical trials. Interim results of the Phase I/II studies demonstrated immunological activity at all doses. EGF-R (the epidermal growth factor receptor) is highly expressed on a significant number of breast, head and neck, brain, non-small cell lung and bladder tumors. MDX-22 is used to purge leukemia cells from the bone marrow of acute myeloid leukemia (AML) patients who are undergoing a transplant of their own bone marrow. Phase II results indicate that MDX-22 can promote long term disease free survival in AML patients. Phase III trials are expected to begin during the first quarter of 1998. MDX-220, a new anti-cancer Bispecific for tumors that express TAG-72, is in the final stages of pre-clinical development. An Investigational New Drug application is expected to be filed with the FDA in 1998. TAG-72 is expressed on a variety of cancers, including lung, colon, prostate, ovarian, endometrial, pancreatic and gastric. ÿ ÿ ÿ ÿ Autoimmune Diseases MDX-33, a monoclonal antibody that binds to FcgR1 receptors, is being developed to treat autoimmune hematological disorders such as Idiopathic Thrombocytopenia Purpura (ITP) and autoimmune hemolytic anemia. In a Phase I study, MDX-33 was well tolerated at a dose that is capable of modulating an immune response implicated in autoimmune diseases. Phase II trials are expected to begin in the first quarter of 1998. MDX-33 is being developed through a corporate alliance with Centeon L.L.C. Secondary Cataract MDX-RA, an immunotoxin designed to prevent secondary cataracts, is Medarex's first product in Phase III clinical trials. Results from Phase I/II studies demonstrated that MDX-RA treatment can reduce the clouding of the eye lens following cataract surgery, that causes secondary cataracts. Completion of the Phase III study is expected in late 2000. Medarex has a partnership with Santen Pharmaceuticals Co., Ltd. for the development and distribution of MDX-RA in Japan. ÿENMD:ÿ Quote ÿ|ÿ Profile ÿ|ÿResearch This Is a Reply to: Msg 1135 by BINGOmmmm View Replies to this Message <- Previous Next -> Message 1136 of 1152Reply ÿÿ ------------------------------------------------------------------------ Go to: Startÿ|ÿMost Recentÿ|ÿMessage List | Message Number:ÿ ÿ ÿ All Boards ÿ Only in this Board ÿ All ÿÿ Boards & Topics ÿ Authors ------------------------------------------------------------------------ Terms and Conditions Yahoo! is a trademark of Yahoo! Inc. Copyright c 1994-98 Yahoo! All Rights Reserved.