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To: patsy who wrote (2669)	5/10/1998 5:50:00 PM
From: patsy	Read Replies (1) \| Respond to of 3448

fyi CANCERLITr Bibliographic Database Detailed Search Results Record 6 UNIQUE ID: 98153903 AUTHOR: Hamad GG, Neifeld JP TITLE: Biochemical, hematologic, and immunologic alterations following hepatic cryotherapy. SOURCE: Semin Surg Oncol; 14(2):122-8 1998 ABSTRACT: Hepatic cryosurgery causes hepatocellular damage primarily by inducing the formation of ice crystals. Cell necrosis is enhanced using two or more freeze-thaw cycles. The resultant damage to hepatocytes induces alterations in a number of biochemical and hematologic parameters, including hepatic function tests, serum bilirubin, serum and urine myoglobin, platelet count, and coagulation measures. Further, in experimental models, cryogenic surgery appears to stimulate the immune system of the host leading to an anti-tumor immune response. These perturbations in biochemical and hematologic parameters are usually transient, and long-term adverse sequelae are uncommon and preventable. (23 Refs) MESH TERMS: Animal Antigens, Neoplasm/Blood Cryosurgery/Adverse Effects Human Liver Function Tests Liver Neoplasms/Blood/Immunology/Metabolism/*Surgery/Urine Myoglobin/Blood Myoglobinuria/Etiology T-Lymphocytes/Immunology Thrombocytopenia/Etiology Tumor Markers, Biological/Blood LANGUAGE: ENG PUBLICATION TYPE: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL TITLE ABBREVIATION: Semin Surg Oncol YEAR: 98 ADDRESS: Department of Surgery, Virginia Commonwealth University 23298, USA. ENTRY MONTH: 9804 CAS NO.: 0 (Antigens, Neoplasm) 0 (Myoglobin) 0 (Tumor Markers, Biological)