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Biotech / Medical : EntreMed (ENMD) -- Ignore unavailable to you. Want to Upgrade?

To: tommysdad who wrote (987)	5/14/1998 1:17:00 AM
From: StockDoc	Respond to of 2135

They're probably right, since angiogenesis requires matrix breakdown, which in turn is catalyzed by MMPs. What's interesting is that the interstitial matrix has a lot of collagen (XVIII is the precursor of endostatin), and some MMPs get activated by plasmin (plasminogen, the zymogen, is the precursor of angiostatin). Could there be a link here? Could AS/ES act along the same pathway as MMPIs? As of the MMP crystal structure, I thought Agouron was doing everything based on that. I guess I was wrong. Thanks for the clarifications. I am interested in the detail, even if it's chemistry and I'm just a doc. StockDoc