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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: HerbertOtto who wrote (20886)5/15/1998 6:04:00 PM
From: tonyt  Read Replies (2) | Respond to of 32384
 
>Earnings 35 cents vs 28 cents est

I believe you mean Loss 35c.

Nice try though :-)

--Tony



To: HerbertOtto who wrote (20886)5/15/1998 6:05:00 PM
From: Peter Singleton  Respond to of 32384
 
fyi, BBC on the Lancet article on Tamoxifen's effectiveness in preventing relapse / death after breast cancer surgery ... btw, looks like The Lancet article was a meta-analysis of a number of trials worldwide.

news.bbc.co.uk

Friday, May 15, 1998 Published at 05:33 GMT 06:33 UK
Sci/Tech
Breast cancer drug hailed as lifesaver
Some researchers believe it is the best cancer drug yet
A study involving 30,000 women has provided the clearest evidence yet of
the life-saving powers of the breast cancer drug Tamoxifen, doctors are
claiming.

James Wilkinson reports on Tamoxifen's rediscovered effectiveness
(1'55")The findings suggest that if the drug is given immediately after
surgery to all patients who need it, irrespective of age, an extra
20,000 lives could be saved worldwide each year.
In Britain, which is already at the forefront of Tamoxifen treatment,
wider use could save an estimated 1,000 lives.

Evidence of benefit to younger women

Tamoxifen is recognised as a powerful weapon against breast cancer in
older women, preventing its spread and stopping recurrence. In the UK it
currently saves about 2,000 lives a year.

But many doctors are under the impression it cannot help pre-menopausal
women under about the age of 50. There is also wide reluctance to
prescribe it in addition to other forms of chemotherapy.

One in 12 British women develop the diseaseThe new results may change
those attitudes. They show that starting Tamoxifen early and continuing
it for around five years halves the rate of breast cancer recurrence,
even in younger patients. Its benefit was additional to that of other
chemotherapy drugs.

Cancer researcher Professor Richard Peto, from Oxford University, said:
"Starting Tamoxifen immediately after breast cancer surgery prevented
one-in-six women from relapsing and one in 12 from dying, irrespective
of age.

"Tamoxifen for older women is already saving more lives than any other
cancer drug, but most of the young breast cancer patients who need
Tamoxifen aren't getting it yet."

'A treatment that works'

The findings, published in the Lancet medical journal, were compiled
from an overview of 55 patient trials in 15 different countries,
co-ordinated at Oxford University.

Professor Peto told a news conference in London: "I've been working in
cancer surgery for 30 years and this is the best result I've ever been
involved with. We have got a treatment that works."

Mounting evidence

The price of the pills in Britain is about a tenth of that in the USThe
findings follows only days after the release of dramatic results from a
large study of the preventative effects of Tamoxifen in America.

The study in Pittsburgh, Pennsylvania, involving 13,000 women at high
risk of the disease because of their age and family history, showed that
Tamoxifen used as a preventative measure could cut cancer rate by nearly
a half.

Britain is taking part in a similar on-going international prevention
study of Tamoxifen.
ÿ



To: HerbertOtto who wrote (20886)5/15/1998 6:16:00 PM
From: Henry Niman  Respond to of 32384
 
Speaking of earnings:
Seragen, Inc. Reports First Quarter 1998 Financials

PR Newswire - May 15, 1998 17:13

SRGN %MTC %ERN LGND V%PRN P%PRN

HOPKINTON, Mass., May 15 /PRNewswire/ -- Seragen, Inc. (OTC Bulletin Board: SRGN) reported
today that the net loss for the first quarter ended March 31, 1998 was $3.6 million, or $0.15 per share on
23,243,684 common shares outstanding as compared to a net loss of $4.6 million, or $0.25 per share on
17,936,675 common shares outstanding for the first quarter of 1997.

Seragen's total operating expenses for the first quarter of 1998 were $2.8 million compared to $4.6 million
for the same period of 1997. The decrease in operating expenses in 1998 was primarily due to savings
associated with the sale of the company's operating division. Seragen's continuing net loss reflects
expenditures associated with ongoing research and clinical trials in the development of its fusion proteins.

Seragen and Ligand Pharmaceuticals Incorporated (Nasdaq: LGND) announced on May 11, 1998 that
they have signed a definitive agreement under which a wholly owned subsidiary of Ligand will merge
with Seragen. The merger agreement has been approved by the board of directors of each company and
is subject to approval by a majority of Seragen's stockholders.

Seragen is a biopharmaceutical company developing a proprietary portfolio of therapeutic products. The
company's unique receptor-active fusion proteins consist of a toxin fragment genetically fused to a
hormone, or growth factor, that targets specific receptors on the surface of disease-causing cells.

Seragen's current focus is on cancer and dermatology. The company has filed a biologic license
application with the U.S. Food and Drug Administration (FDA) requesting clearance to market
ONTAK(TM) (DAB389IL-2 or denileukin diftitox) for advanced cutaneous T-cell lymphoma. The
application has been designated for "priority" review and is scheduled for discussion at the June 2, 1998
meeting of the Oncologic Drugs Advisory Committee, a panel of advisors to the FDA. Seragen is
conducting clinical trials of the same molecule for psoriasis. A second product, EGF Fusion Protein, is
currently in a Phase I/II clinical trial for solid tumors.

Safe Harbor Information

Some of the statements contained in this document are forward-looking, including statements relating
directly or by implication to Seragen's products, operations, strategic partnerships, financial condition, and
to Seragen's ability to fund its operations, and Seragen's ability to consummate the transactions
contemplated by its agreements with Ligand Pharmaceuticals Incorporated and related agreements.
These statements are based on current expectations and involve a number of uncertainties and risks,
including (but not limited to) Seragen's ability to proceed with successful development, testing, and
licensing of its products, Seragen's ability to continue to fund its operations, and Seragen's ability to
consummate the transactions contemplated with Ligand Pharmaceuticals Incorporated and related
agreements. For further information, refer to the "Business Outlook" section in Seragen's Form 10-K as
filed with the Securities and Exchange Commission. Actual results may differ materially from such
expectations. SERAGEN, INC. BALANCE SHEETS

Assets December 31, 1997 March 31, 1998
(Unaudited)
Current assets:
Cash and cash equivalents $5,328,535 $4,588,786
Restricted cash 175,000 200,000
Contract receivable 208,190 634,233
Unbilled contract
receivable 944,063 1,014,994
Prepaid expenses and
other current assets 72,065 71,442
Total current assets 6,727,853 6,509,455

Property and equipment, net 15,064 13,054
Deferred commission 2,060,000 2,060,000
Other assets 8,648 9,324
Total assets 8,811,565 8,591,833

Liabilities and Stockholders' (Deficit)
Current liabilities:
Accounts payable 447,008 264,206
Related Party Payable 3,422,833 5,887,835
Dividend Payable - Series B
Preferred Stock 2,943,136 3,528,383
Accrued expenses 2,240,435 1,678,640
Preferred stock
redemption liability --- 4,530,461
Short-term obligation. 800,000 800,000
Total current liabilities 9,853,412 16,689,525

Non-current liabilities:
Deferred revenue 10,000,000 10,000,000
Long-term obligation 1,450,000 1,450,000
Canadian affiliate put
option liability 2,400,000 2,400,000
Total non-current
liabilities 13,850,000 13,850,000

Commitments and contingencies
Stockholders' (deficit);
Convertible preferred stock,
Series B, $.01 par value;
issued and outstanding
23,800 shares at
December 31, 1997 and
March 31, 1998, respectively
$23,800,000 at
liquidation preference 23,800,000 23,800,000
Convertible preferred stock,
Series C, $.01 par value;
issued and outstanding
5,000 and 0 shares at
December 31, 1997, and
March 31, 1998,
respectively at
$5,500,000 liquidation
preference 5,500,000 ---
Convertible preferred stock,
Series D, $.01 par value;
issued and outstanding
908 and 310 shares at
December 31, 1997, and
March 31, 1998, at
$1,023,231 and $354,926
respectively,
liquidation preference 1,023,231 354,926
Common stock, $.01 par value;
70,000,000 shares authorized;
issued 21,444,894 and
27,273,857 shares at
December 31,1997
and March 31, 1998,
respectively 214,448 272,731
Additional paid in capital 160,957,800 163,571,997
Accumulated deficit (206,384,995) (209,945,015)
(14,889,516) (21,945,361)
Less-treasury stock
(777 shares at cost at
December 31,1997 and
March 31, 1998,
respectively) (2,331) (2,331)
Total stockholders'
(deficit) (14,891,847) (21,947,692)
Total liabilities and
stockholders' (deficit) $8,811,565 $8,591,833

SERAGEN, INC.
STATEMENT OF OPERATIONS
(Unaudited)

For the three months
ended March 31,
1997 1998

Revenue:
Contract revenue and
license fees $911,625 $747,174

Operating expenses:
Cost of contract revenue 882,034 747,098
Research and development 2,516,840 1,494,661
General and
administrative 1,189,803 606,281
4,588,677 2,848,040

Loss from operations (3,677,052) (2,100,866)
Interest income 14,703 44,145
Interest expense 172,366 ---

Net loss (3,834,715) (2,056,721)

Preferred stock
dividends and accretion 720,703 1,503,299

Net loss applicable
to common stockholders ($4,555,418) ($3,560,020)

Net loss per
common share $(0.25) $(0.15)

Weighted average
common shares used in
computing net loss
per share 17,936,675 23,243,684

SOURCE Seragen, Inc.

/CONTACT: Lora Maurer of Seragen, Inc., 508-435-2331/

(SRGN)



To: HerbertOtto who wrote (20886)5/15/1998 6:18:00 PM
From: Henry Niman  Respond to of 32384
 
I think that if LGND actually made $0.35 in 1Q '98, LGND's price would have moved up quite a bit more than 5/16!



To: HerbertOtto who wrote (20886)5/15/1998 6:18:00 PM
From: Henry Niman  Respond to of 32384
 
I guess bob missed it.