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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: tony who wrote (21609)6/1/1998 11:06:00 AM
From: tonyt  Respond to of 32384
 
>How does it impact LGND?

Down 1/8th



To: tony who wrote (21609)6/1/1998 11:30:00 AM
From: Henry Niman  Respond to of 32384
 
David Favor just did a report on the Analyst conference call. Both stocks had started the day lower, and both had subsequently moved into positive territory,

The two CEOs held the conference call (and they will be on CNBC at 12:30) and emphasized the need for deep pockets to compete, both in the Pharma area as well as Agro. The emphasis was on the pipeline, which they said is now #1. They also acknowledged that it takes a long time to develop the pipeline.

LGND of course has an excellent pipeline (see home.att.net or home.att.net ) and of course the new company will put emphasis on development. For LGND there is no overlap since they don't have an alliance with MTC and the Women's Health Alliance with AHP is quite large (and impacts AHP's #1 seller, Premarin).

The Favor report also mentioned dilution until 2001, close at the end of the year, no anti-trust concerns, and a review of the MTC options plan for executives.



To: tony who wrote (21609)6/1/1998 11:46:00 AM
From: Henry Niman  Respond to of 32384
 
AG Edwards analyst Kenneth Nover was just on CNBC. He thought deal was a plus for both companies. For AHP it brought about critical mass in Pharma products and research. For MTC they needed to add to their Searle subsidiary.

There would be economies of scale, but chief cost benefit would be cost avoidance. MTC had to beef up international sales, and AHP offers infrastructure.

He thought that dilution was a short term concern, but would lead to greater long term growth. Expected the deal to close in early 4Q and saw new company as a stronger competitor, but wouldn't impact any one drug company in particular.



To: tony who wrote (21609)6/1/1998 11:52:00 AM
From: Andreas Helke  Read Replies (4) | Respond to of 32384
 
Du Pont no longer has a chance to acquire Monsanto. Since they plan to transform themselves into a life science company they may be forced to buy smaller biotechs like Ligand.

Andreas



To: tony who wrote (21609)6/1/1998 3:22:00 PM
From: Henry Niman  Respond to of 32384
 
Here's more from Dow Jones:
Dow Jones Newswires -- June 1, 1998
Amer Home Gets Biotech
Presence;Monsanto Gets Mktg Strength

By Gaston F. Ceron

NEW YORK (Dow Jones)--In agreeing to merge with Monsanto Co.
(MTC) in a deal valued at more than $34 billion, American Home Products
Corp. (AHP) has established a strong foothold in the growing
biotechnology field, while Monsanto addressed important growth issues
about its pharmaceuticals business.

By teaming up with American Home Products, a leading pharmaceutical
company with a strong international presence, Monsanto will get access to
the marketing and research and development resources it needs to grow its
pharmaceuticals operations adequately. And with the addition of American
Home Products' American Cyanamid Co. unit, Monsanto will get some
additional marketing power for its agricultural chemicals.

"The bottom line is (that) Monsanto was getting more and more
resource-constrained," said Donald Carson, chemicals analyst at J.P.
Morgan Securities Corp.

Meanwhile, American Home Products will get to add to its portfolio what
many consider to be the premier company in the fast-growing area of
agricultural biotechnology, a field that seeks to enhance the quality of crops
by genetically altering seeds - and one where American Home Products
was lacking. Applications include seeds designed to withstand certain
herbicides and pests, making farming a more efficient business.

"Biotechnology has been focusing on human disease from the beginning of
its existence," said Edmund Debler, who follows American Home Products
for Mehta Partners in New York. "Ag biotech will become much more
forceful from now on."

Monsanto's efforts have been aimed at dominating this industry; the
company divested its chemicals business last year and has acquired a string
of companies, including recently announced agreements for DeKalb
Genetics Corp. (DKB) and Delta & Pine Land Co. (DLP), two leading
seed producers that will give Monsanto's seed traits an effective delivery
mechanism.

And as agricultural applications grow, they are expected to go beyond
making life easier for farmers and expand into products that provide value
to consumers, such as foods that are designed to have added nutritional
value.

For American Home Products, the reasons for wanting a solid presence in
this field can be best understood by looking at the financial picture. Debler
estimates the combined company, helped by the biotechnology offerings,
will have $7.6 billion in agricultural products sales by 2001, up from an
estimated $5.6 billion in 1998. It will also surpass Novartis AG as the
world's largest agricultural products company.

Through the merger with American Home Products, Monsanto will also get
somewhat of a comfort zone over its chief biotechnology rival, DuPont &
Co. (DD). DuPont recently said life sciences will be the centerpiece of its
future business, competing with Monsanto for growth.

The additional resources American Home Products brings to the table will
make Monsanto a "more formidable foe," said J.P. Morgan's Carson. And
the merger effectively removes two companies that DuPont could have
tried to align itself with, he added. One of the hot Monsanto rumors in the
weeks leading up to the merger was that DuPont would try to acquire the
company. DuPont officials weren't immediately available to comment on the
merger.

Still, as with every deal, there are potential downsides. James Hickman, a
chemicals analyst who follows Monsanto for Credit Suisse First Boston
Corp., said an agreement between Monsanto and Pfizer Inc. (PFE) to
market Celebra, an arthritis treatment, doesn't seem like such a good deal
now. Under the merger arrangement, Hickman said, American Home
Products would have been better suited to help market the product. An
analyst who covers Monsanto said the Pfizer agreement is expected to
continue.

Monsanto and Pfizer officials weren't immediately available to comment on
Celebra.

The merger carries $700 million in breakup fees, executives said during a
conference call with reporters. Monsanto was advised by Goldman Sachs
& Co., while American Home Products retained Bear Stearns & Co. - By
Gaston F. Ceron; 201-938-5166 gaston.ceron@cor.dowjones.com



To: tony who wrote (21609)6/2/1998 5:54:00 AM
From: Henry Niman  Respond to of 32384
 
Here's what FT had to say about the AHP/FTC merger:
Monsanto and AHP to merge
By Nikki Tait in Chicago and Will Lewis in New York

<Picture: MONSANTO>Two of the top science-based companies in the US yesterday announced a $34bn (œ20bn) merger deal to create a broad-based "life sciences" group encompassing pharmaceuticals, agricultural products and food ingredients.

American Home Products, the East Coast-based drugs and pharmaceutical group, will, in effect, take over Monsanto, whose interests range from pharmaceuticals and food ingredients to biotechnology. The combined stock market valuation of the two com-panies is $96bn.

The deal is one of the most dramatic moves in a growing trend by research-based companies to weld a wide range of businesses built on biology. They include DuPont of the US, Novartis of Switzerland, Hoechst and Bayer of Germany, Rh“ne-Poulenc of France and Zeneca of the UK.

The yet-to-be-named company, in which AHP will hold a 65 per cent stake, will have annual sales of about $23bn, employ 75,000 people and put about $3bn a year into research and development. Pharmaceuticals will be the largest element, accounting for about half the group's sales and two-thirds of the annual R&D budget. Agricultural interests, mainly derived from Monsanto and ranging from genetic engineering to herbicides, will be the second element. Sales in this area will be about $6bn a year.

In New York lunchtime trading, Monsanto's shares were down $ 5/8 at $54_ and American Home Products' shares were up $_ at $49 1/16.

John Stafford, AHP's chief executive, and Robert Shapiro, his counterpart at Monsanto, said the merger had been triggered by the need to ensure strong finance, research and marketing resources in the rapidly-consolidating life sciences industry.

Both companies have been in the merger frame recently. AHP, with annual sales of about $14bn, attempted to merge with SmithKline Beecham to create a more powerful pharmaceuticals business.

The deal broke up partly because of concern about two of AHP's anti-obesity drugs, which were withdrawn from the market after evidence that they caused heart valve defects. In spite of large potential liability claims, the company was determined not to "fall behind in what is proving to be a fast consolidating pharmaceutical industry", according to one adviser, and many analysts had expected it to find another deal.

Monsanto's aggressive push into life sciences and a spate of multi-billion dollar acquisitions - large relative to its $7bn annual sale base - had led to speculation that it would need a bigger partner.

AHP shareholders will retain their shares while Monsanto shareholders will receive 1.15 shares in the new company for each existing Monsanto share, giving them about 35 per cent of the equity.

By contrast, the 22-member board will be divided equally between AHP and Monsanto. Mr Shapiro and Mr Stafford will be co-chairman and co- chief executives.

Unusually, the merger agreement carries a $700m break-up fee, payable if another buyer emerges for Monsanto. While such fees are fairly common, the size raised eyebrows among investment bankers.



To: tony who wrote (21609)6/2/1998 6:10:00 AM
From: Henry Niman  Respond to of 32384
 
Here's the NY Times report on the deal:
June 2, 1998

American Home Products to Acquire Monsanto for $34.4 Billion

------------------------------------------------------------------------
Related Articles
 The Bet: Strategy as Intricate as a Double Helix
 Merger Gives Monsanto Chief Big Windfall Profit

Forum
 Join a Discussion on Merger Mania
------------------------------------------------------------------------

By DAVID J. MORROW

<Picture: N>EW YORK -- In the largest deal ever in the pharmaceuticals industry, American Home Products Corp. announced on Monday that it would acquire Monsanto Co. for $34.4 billion in stock.

The combined company will be the nation's top seller of prescription drugs and a world leader in insecticides and other agricultural products. The company's name brands also include such household names as Advil painkiller, Centrum vitamins and Nutra Sweet sugar substitute.

The deal surprised Wall Street, which had long expected American Home Products, based in Madison, N.J., to sell its agricultural business instead of expand it. Yet, by merging with Monsanto, American Home Products will be able to double its research spending to $3 billion annually, add several new drugs to its pipeline and bolster its position in genomics research, a process which uses genes to develop drug compounds.

"We started talking recently and it made sense to put our companies together," said John Stafford, the chairman of American Home Products. "We will have a new company with global presence that can deliver the new (Monsanto drug) products to the market. We'll be number three or four in the world when it comes to pharmaceuticals, up from number six."

Investors reacted coolly to the deal. Shares of American Home Products crept up 93.75 cents, to $49.50, while Monsanto fell 87.5 cents, to $54.50. Several factors may explain the muted response. Officials from American Home Products said the acquisition would dilute the company's earnings by 15 percent the first year and a lesser amount after that.

Although both companies described the deal as a merger of equals, American Home Products is in effect purchasing Monsanto. Under the terms, American Home Products will swap 1.15 of its shares for each Monsanto share and will control 65 percent of the new company's stock.

"American Home Products appears to be taking control of Monsanto," said Neil Sweig, a pharmaceuticals analyst with Southeast Research Partners. "But the new board will be divided up evenly between the two companies. It will be interesting to see how well the two companies integrate."

The acquisition may have averted a crisis at both companies. Analysts noted that the deal, which would create a combined company with $96 billion in market capitalization and $23 billion in sales, would help American Home Products cover its legal liabilities over its diet drugs, Redux and Pondimin, one half of the combination known as fen-phen.

American Home Products recalled the drugs last September at the request of the Food and Drug Administration, after studies showed the pills could cause heart damage. A flood of lawsuits from the 6 million people who used the drugs quickly followed, and analysts now estimate American Home Product's liabilities could be as high as $5 billion.

Monsanto's problems were not quite so dire. The St. Louis-based company had recently spun off its chemical division to concentrate on agricultural products and biotechnology. Yet, it had little chance of fully marketing its wares without merging with a company like American Home Products, a firm twice its size.

"There is no doubt that the new company will be stronger," said Dr. Daniel Vasella, president and chairman of the executive committee of Novartis AG in Basel, Switzerland. "Strategy is nothing unless you can implement it properly but I believe they will succeed in combining the cultures."

Analysts appear to be more confident that the two companies' portfolios will meld better than than boardrooms. American Home Products and Monsanto are two of the world's largest sellers of agricultural products, including Roundup, the world's most popular herbicide, and namebrand insecticides like Counter and Fastac.

Even more important, however, both companies are well anchored in pharmaceutical and consumer products. Monsanto sells Nutra Sweet, a popular sugar substitute, as well as Ambien, a leading treatment for insomnia, marketed through Searle, its pharmaceutical division.

As with any pharmaceutical acquisition, this one will produce a deep pipeline. Monsanto has five drugs that should enter final stage of trials this year, while American Home Products could launch several top selling drugs within the next several years, including Embrel, a joint venture with Immunex for rheumatoid arthritis.

Prior to the deal, both companies were outpaced by their competitors on research and development spending. American Home Products spent $1.5 billion on research and development last year, while Pfizer spent $2 billion and Merck $1.683 billion.

Once the acquisition is completed, American Home Products and Monsanto will spend $3 billion annually on research -- $2 billion on pharmaceuticals and $1 billion on agriculture. The company also expects to save $1.2 billion to $1.5 billion annually in cost savings within three years of the deal's closing.

Yet, the deal also raises some hard questions. The two companies have different cultures that may clash. For example, the combined company has yet to be named and the two chief executives, Stafford at American Home Products, and Robert Shapiro at Monsanto, will run the company as joint chairmen.

In what appears to be a further ingredient to a corporate turf battle, the company's top four jobs are divided equally between the two companies. Robert Blount, a senior executive vice president at American Home Products, will be the new company's chief financial officer. Robert Essner, American Home Products executive vice president, will head the pharmaceuticals business. Monsanto Vice Chairman Richard U. De Schutter will run the consumer health care and nutrition division and Hendrik Verfaillie, Monsanto president, will run the agricultural and animal health businesses.



To: tony who wrote (21609)6/2/1998 6:14:00 AM
From: Henry Niman  Respond to of 32384
 
Here's a Reuter's thumbnail sketch:
Profiles of American Home products and Monsanto

DATELINE, June 1 (Reuters) - Following are key facts about American Home Products Corp and Monsanto Co, which announced a $33 billion merger.

American Home Products Corp.

Chairman: John Stafford

1997 income: $2.0 billion

1997 sales: $14.2 billion

Employees: More than 52,000

Headquarters: Madison, N.J.

Web site: http:/www.ahp.com

Stock symbol: AHP

Thumbnail: World's No. 6 pharmaceutical company in terms of sales. Major presence in the over-the-counter market with such products as Advil pain relievers, Centrum vitamins, Chap Stick lip balms, Preparation H hemorrhoid treatment, Robitussin cough syrups. Pharmaceuticals include Premarin hormone replacement therapy for menopausal women, Lodine and other anti-inflammatory drugs and long list of cardiovascular drugs. Other products include herbicides, insecticides, animal drugs, medical devices.

History: Founded in 1926. Began buying other companies in earliest years. In 1931, bought John Wyeth & Brother Inc. from Harvard University. Twelve years later, acquired Ayerst Laboratories, maker of Premarin. In 1957, Whitehall Pharmacal Co., original member of American Home Products, became Whitehall Laboratories, which began selling Advil over the counter in 1984. In 1989, bought A.H. Robins, maker of Chap Stick, Robitussin and other products. In 1994, acquired American Cyanamid. Two years later, bought Genetics Institute, a biotech company specializing in drugs for people. ----------------------------------------------------------------

Monsanto Co.

Chairman: Robert Shapiro

1997 income: $470 million

1997 sales: $7.5 billion

Employees: More than 20,000

Headquarters: St. Louis

Web site: http:/www.monsanto.com

Stock symbol: MTC

Thumbnail: Makes wide variety of products, including consumer products such as NutraSweet, the leading sugar substitute; farm products such as Roundup herbicide; Ortho garden products; Searle drugs, including oral contraceptives; and drugs to boost cows' milk output. Monsanto is betting on genetically engineered crops as the key to its future; it owns or has a stake in several seed companies and last month announced plans to buy two of the largest U.S. seed companies for $4.4 billion.

History: Founded in St. Louis as Monsanto Chemical Works in 1901 by John F. Queeney, a drug industry veteran. Names company after wife Olga Mendez Monsanto. Begins making first product -- sugar substitute saccharin -- in 1902, shipping nearly all output in 1903 and 1905 to growing company called Coca-Cola. First public stock sale in 1927. Involved in uranium research during World War II to develop the atomic bomb. AstroTurf, the artificial stadium surface, invented in 1966 based on Monsanto carpet technology. From 1995 to 1997 buys or establishes partnerships with a number of U.S. and foreign life sciences companies, including two of largest U.S. seed companies. In 1997, spins off chemical businesses as Solutia Inc. to focus on life sciences. Sources: Companies; Hoovers Company profiles. REUTERS

04:26 06-02-98



To: tony who wrote (21609)6/2/1998 6:17:00 AM
From: Henry Niman  Respond to of 32384
 
Here's a Reuter's review of the deal:
Merger seen filling gap in AHP agriculture arena

By Ransdell Pierson

NEW YORK, June 1 (Reuters) - The planned merger of American Home Products Corp. <AHP.N> and Monsanto Co. <MTC.N> is a logical marriage that will allow AHP to catapult its important crop-protection business into the genetics age, analysts said.

Analysts said that while AHP is a player in the herbicide and agricultural chemicals arena, it has not focused on biotech agriculture applications such as insect-resistant seeds, which are among Monsanto's strong suit.

"AHP has been widely underappreciated as an agricultural company, with some people regarding its agricultural business as an unwanted appendage," said Sam Isaly, a principal of the New York investment research firm OrbiMed Advisors.

"By merging with Monsanto, American Home will be getting into a highly attractive growth opportunity in agriculture," Isaly said, noting Monsanto's expertise in genetically engineered crops.

Monsanto boosted its high-tech agricultural profile with its announcement last month that it intended to acquire DeKalb Genetics Corp. <DKB.N> and Delta & Pine Land Co. <DLP.N>, two of the nation's largest seed companies, for $4.4 billion.

Monsanto predicts farmers will plant its gene-altered products on about 50 million acres this year, 2-1/2 times the 20 million acres seeded in 1997.

Among Monsanto's most popular products are soybean, cotton and corn seeds that are altered to resist crop-eating pests and to tolerate Monsanto's cash-cow Roundup herbicide.

Isaly said AHP's crop-protection products, which include Pursuit and Prowl herbicides as well as fungicides and insecticides, are largely an outgrowth of its $9.6 billion acquisition in 1994 of American Cyanamid Co.

"People seem to have forgotten that AHP bought a big agricultural business when they bought American Cyanamid," Isaly said, although over $2.1 billion of AHP's revenues of $14.2 billion in 1997 were from agricultural products.

Viren Mehta, of the New York research firm of Mehta Partners, said AHP would acquire "valuable tools of biotech" agriculture in acquiring Monsanto, including expertise in plant biology, chemistry and genomics.

He said the expertise would enable the new entity to generate likely agricultural-related sales of almost $8 billion by 2001, which he called an impressive sum even though it would be eclipsed by pharmaceutical sales of about $18 billion.

"AHP and Monsanto is a perfect merger," said Hambrecht & Quist analyst Alex Zisson.

"AHP has expertise in chemicals but not in exotic biotech areas of agriculture, including genetically engineered seeds and specialty herbicides and other products designed to work with specially designed seeds. The new entity will have both areas covered," Zisson said.

Zisson said Monsanto alone would not have the financial might to fully exploit its biotech knowledge. "But with AHP's deep pockets, it could do more and more research on other seeds and designer chemicals."

Isaly said Novartis AG <NOVZn.S> of Switzerland, with crop protection and seed sales of over $5 billion in 1997, would remain the world leader in the field among so-called "life science" companies that make prescription drugs as well as agricultural products.

19:16 06-01-98



To: tony who wrote (21609)6/2/1998 6:21:00 AM
From: Henry Niman  Respond to of 32384
 
Here's what WSJ had to say:
American Home Products,
Monsanto Agree to Combine

Stock Swap Valued at $35.08 Billion Is Tied
To Genetics Revolution in Agriculture, Medicine

By ELYSE TANOUYE and JAMES P. MILLER
Staff Reporters of THE WALL STREET JOURNAL

American Home Products Corp. agreed to acquire Monsanto Co. in a $35.08 billion stock swap, driven by a revolution in genetics that is bringing significant medical and agricultural advances.

The proposed deal would create a new, as-yet-unnamed powerhouse in the pharmaceutical, nutrition and agriculture industries. In what the companies called a "merger of equals," American Home shareholders would own about 65% of the new concern. But the two companies agreed that their chairmen would become co-chairmen and co-chief executive officers and that American Home and Monsanto would have equal representation on the new company's board.

ÿÿ<Picture: CNBC Dow Jones Business Video>ÿÿ<Picture: Media>CEOs Speak
American Home Products' John Stafford and Monsanto's Robert Shapiro discuss their companies' merger.ÿÿ<Picture: Learn About CNBC/Dow Jones Business Video>
<Picture: Get started with audio/video>

Both companies have well-known consumer products -- American Home makes Advil and Chap Stick, while Monsanto makes Nutrasweet. But both now are racing against competitors to develop and commercialize results of the recent explosion of discoveries in genetics and automated chemistry. The technology breakthroughs are creating vast opportunities for new products, but the costs are devouring research-and-development budgets throughout the drug and agricultural industries. One solution: pooling resources to create huge research houses that have the budgets and expertise to exploit the emerging science.

"People are racing to identify [gene] targets, and in some instances the winners will be the ones who get there first," said John Stafford, chairman, president and chief executive of American Home, Madison, N.J., where the new company will be based. "We think we can run faster together."

------------------------------------------------------------------------

The Making of a Medical Titan

ÿ ÿÿÿÿÿÿÿÿAmerican
ÿÿÿÿHome Products ÿÿÿÿÿMonsanto-a Headquarters ÿÿÿÿÿÿMadison, N.J. ÿÿÿÿÿÿSt. Louis 1997 Revenue ÿÿÿÿÿÿ$14.2 billion ÿÿÿÿ$7.51 billion 1997 Profits ÿÿÿÿÿ$2.2 billion-b ÿÿ$294 million-c Employees ÿÿÿÿÿÿÿÿÿÿÿ59,600 ÿÿÿÿÿÿÿÿ21,900

a-Financial figures exclude contributions from Monsanto's chemical businesses which were spun off in Sept. 1997.
b-Net income
c-Income from continuing operations

Moving Up the Ranks

Listed by percent of global market share of 1998 projected pharmaceutical sales

Merck ÿÿÿÿÿÿÿÿ4.70% Glaxo Wellcome ÿÿÿÿÿÿÿÿ4.19% Novartis ÿÿÿÿÿÿÿÿ3.62% Pfizer ÿÿÿÿÿÿÿÿ3.44% Bristol-Myers Squibb ÿÿÿÿÿÿÿÿ3.38% AHP-Monsanto ÿÿÿÿÿÿÿÿ3.12% SmithKline Beecham ÿÿÿÿÿÿÿÿ2.61%

Sources: the companies; Tradeline; Baseline

------------------------------------------------------------------------

The agreement follows a failed attempt by American Home this year to merge with SmithKline Beecham PLC, one of the first companies to move aggressively to harness gene and chemistry technologies to discover pharmaceuticals. SmithKline dropped the American Home negotiations in favor of a deal with Glaxo Wellcome PLC, but that effort fell apart over management-control issues. Now other companies, including Pfizer Inc., Glaxo and Bristol-Myers Squibb Co., are gaining access to new technologies by acquiring or collaborating with smaller biotechnology companies.

<Picture: [Go]>Merger Is Experiment in Splicing Together Two Chief Executives

<Picture: [Go]>Once a Floundering Business, Searle Is Now Pharmaceutical Plum

<Picture: [Go]>Old Rivals Monsanto and DuPont Fight Over New Turf -- Biotech Crops (May 27)

<Picture: [Go]>The Competition in Crop Biotechnology Intensifies the Players' Need for Cash (May 15)

<Picture: [Go]>Monsanto, Cargill Team Up for Crop-Biotechnology Race (May 15)

<Picture: [Go]>Monsanto CEO Races to Build Crop Biotechnology Power (May 13)

<Picture: [Go]>DuPont Plans to Sell Off Conoco, Clearing Way for Biotech Growth (May 12)

<Picture: [Go]>Monsanto Buys Crop-Biotech Firms In Cash, Stock Deals of $4.2 Billion (May 12)

Terms of the latest combination call for American Home stockholders to get shares in the new company on a 1-for-1 basis. Monsanto holders would receive 1.15 shares of the new company for each current share held.

In New York Stock Exchange composite trading Monday, American Home shares rose 93.75 cents to $49.25. At that price, the exchange ratio for the merger would provide Monsanto holders with stock valued at $56.6375 a share and value the deal at $35.08 billion, based on 619.4 million shares outstanding. It would be the sixth-largest corporate merger in history.

Monsanto shares slipped 87.5 cents in heavy Big Board trading Monday, to close at $54.50, still up more than 40% from the $38.3125 the shares fetched as recently as January, in part due to speculation about a takeover.

Wall Street observers had expected St. Louis-based Monsanto to seek a partnership or alliance, because its corporate pockets aren't deep enough to match the research at larger competitors, such as Novartis AG of Switzerland and DuPont Co., that are also making big biotech bets.

DuPont especially had been rumored to be a potential suitor of the Midwestern company, but people on Wall Street Monday put a low probability on its breaking up the engagement with a higher offer. A DuPont-Monsanto combination might raise antitrust issues, for instance, and some people see a possible culture clash between the conservative management approach at DuPont and the more new-age style at Monsanto. In addition, there is a $700 million payment in the deal for American Home if a third party breaks up the combination.

Robert B. Shapiro, Monsanto's chairman and chief executive, has drawn high marks for successfully redefining the onetime chemical producer as a crop-biotech leader. But the acquisitions that helped reposition Monsanto have been pricey, the company's research outlays are growing more burdensome, and the payoff for a number of promising high-tech agricultural projects lies well in the future.

In addition, U.S. patents on the popular agricultural herbicide Roundup, which has served as Monsanto's cash cow for the past several years, are set to expire in 2000.

This has set the stage for takeover talk, and Mr. Shapiro had done little to damp the conjecture. Indeed, for the past several weeks he has publicly signaled his interest in some sort of alliance with a health-related company, to help Monsanto avoid having its ambitious effort in the increasingly fast-moving agricultural-biotech field crimped for lack of funding.

"We talked to a lot of people," Mr. Shapiro said in a news conference Monday. But Monsanto found American Home "by far the most attractive" partner.

------------------------------------------------------------------------

Monsanto's Transformation

Milestones on the road from chemicals to "life-sciences":

1994

CEO Richard J. Mahoney discloses plans to retire, ending a 12-year tenure in which Monsanto acquired Searle, shed low-margin petrochemical operations and expanded its ag-chem lines. Robert B. Shapiro named to succeed him.

1995

Sells styrenic plastics business for $580 million.

1996

Buys 40% common stake in DeKalb Genetics Corp. for $170 million. Buys plant-biotech assets of W.R. Grace & Co.'s Agracetus unit Buys controlling interest in Calgene Inc.

1997

Buys Holden's Foundation Seeds and Corn States Hybrid Spins off chemicals business

1998

Agrees to pay a combined $4.2 billion to buy remaining 60% of DeKalb Genetics, and Delta & Pine Land Co. Amid speculation company may need deeper pockets, Shapiro says Monsanto lacks critical mass to achieve all his goals for it in the biotech realm. Agrees to combine with American Home Products.

------------------------------------------------------------------------

The merged company "is designed to be successful in the face of continued consolidation and increasing world-wide competition in the life sciences," Mr. Shapiro said. It "will have the scientific depth, global marketing capabilities and financial resources to take greater advantage of the opportunities before us and to bring innovative new products to market faster."

The deal still leaves open the issue of who will lead the new company in the future, because Mr. Stafford is 60 years old and Mr. Shapiro is 59. Last year Mr. Stafford underwent surgery for prostate cancer, and although he says he is healthy and robust, his health problems brought to the forefront the company's lack of an heir apparent. Indeed, American Home's attempt to merge with SmithKline was seen partly as an effort to resolve the management-succession uncertainty.

Monday, Mr. Stafford said the shared leadership arrangement of the new company will be in place at least over the next year or two until the two companies are fully integrated.

The American Home-Monsanto engagement renewed talk that other deals might follow. Speculation has swirled recently that Hoechst AG will become a takeover target of Swiss drug giant Roche Holding Ltd. and Bayer AG. Both companies declined to comment. Hoechst officials, however, played down deal-making rumors.

Combining Monsanto's and American Home's pharmaceuticals business comes as Monsanto is seeking to launch an important new painkiller. Monsanto's Searle unit, while small by industry standards, will soon seek approval to market the promising drug in the so-called COX-2 class, which many industry observers believe will be a blockbuster profit producer. American Home's drug business, dominated by the menopause drug Premarin, is larger, but its growth prospects were hurt by its recall of diet drugs Redux and Pondimin last year, over which it faces several lawsuits.

Searle already has an agreement with Pfizer Inc. to co-market the COX-2 drug, to be named Celebra, and that agreement isn't going to be affected by the merger, the companies said. The drug is expected to compete with a similar product being developed by Merck & Co.

American Home brings to the combination its ability to market drugs world-wide, a capability Searle needed. Combining the companies' pharmaceutical and agriculture research budgets, a huge $3 billion a year, will also allow them to eliminate duplicative costs and focus resources on the best candidates between the two companies. It will also allow them to apply the new gene science to the agricultural field, where genetics is helping scientists create hybrid plants that are more resistant to disease, drought or spoilage.

The combination reflects the growing "convergence of the agriculture, pharmaceutical and nutrition businesses," said Furman Selz LLC analyst Mark Wiltamuth. The heavy cost of that new technology is accelerating the mergers, he said.

As a result of its corporate "re-engineering" and a number of well-conceived pharmaceutical and agricultural-biotech research efforts, Mr. Wiltamuth said, "Monsanto has built the largest new-product opportunity in its history... . With American Home, we think they'll be able to more comfortably finance these projects."

The two companies said they expect that within three years the merger will yield annual cost savings of $1.25 billion to $1.5 billion, including from some layoffs. In a joint release, they said that assuming the merger is completed by year end, dilution associated with the transaction would reduce American Home's per-share earnings by 15% in 1999 and a lesser amount in 2000; the deal would start to add to earnings the following year.

Because Monsanto's shares trade at a richer price/earnings multiple than American Home's, the companies said the transaction is dilutive to American Home's shares on the order of 15% in the first year after closing.

Bear, Stearns & Co. and the law firm Simpson Thacher & Bartlett advised American Home. Monsanto was advised by Goldman, Sachs & Co., received a fairness opinion from Robertson Stephens & Co. and used Wachtell, Lipton, Rosen & Katz as legal advisers.

The Federal Trade Commission, not the Justice Department, probably will review the merger, because the agency has handled most drug mergers in recent years. While antitrust experts Monday said there didn't seem to be insurmountable product overlaps, the FTC in recent years has insisted on preserving competition in products that aren't yet on the market, sometimes forcing divestitures or licensing of research.

--Steven Lipin contributed to this article.



To: tony who wrote (21609)6/2/1998 6:23:00 AM
From: Henry Niman  Respond to of 32384
 
CNBC has indicated that a merger between Hooks and Bayer is being seriously discussed.