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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: Henry Niman who wrote (21904)	6/5/1998 1:50:00 PM
From: dwight martin	Respond to of 32384

This was the other one. I think everybody knows about this'n too. 5707803 : DNA regulatory elements responsive to cytokines and methods for their use ------------------------------------------------------------------------ INVENTORS:Lamb; Ian Peter, San Diego, CA Seidel; H. Martin, San Diego, CA ASSIGNEES:Ligand Pharmaceuticals, Inc., San Diego, ABSTRACT:ÿÿ The present invention provides oligonucleotide sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription. U.S. REFERENCES: none (No patents reference this one)