To: seminole who wrote (17 ) 6/15/1998 7:37:00 PM From: ACC Read Replies (2) | Respond to of 459
<<Something is not right here. Those Phase I references are very old. >> richard, i absolutely agree with you... i posted those references because i agreed with Your Highness' cautionary comments:Message 4849387 The text of the 504 was rather vague about details not of the offering, but of the science behind the offering. I used the Entrez browser- www3.ncbi.nlm.nih.gov to try to track down any info about the scientist driving CRS (RW Urban) and/or the product "NPP5". It is possible I missed some later Phase 1 data, but i don't think so... if you search under "ImuVert" there are recent citations, mostly researchers looking at the immunomodulatory effects, but nothing more recent regarding clinical trials. There is a reference in a nursing journal that mentions a Phase II - I haven't pulled the article to see if the authors actually cite any reference to that trial. As for Dr. Urban's publications, the phase I trial he appears to be involved in indeed was published in 1992. So... draw your conclusions. Furthermore, ImuVert appears to be a liposomal preparation from bacteria (Gram negative Serratia, FWIW)... so basically, it nonspecifically turns up the immune response. It might work... although I'm partial to the anti-angiogenic approach, which also remains to be proven, but just seems more elegant - I just lucked out. If a hapless reporter hadn't cornered Watson over hors d'oeuvres, ENMD would still be parked at 8-15/share, which is where it probably (unfortunately) will wind up. When? I haven't a clue. So, after a very long-winded reply, I agree with zgoodman that ENMD is overvalued. KCAP/CRS may very well be undervalued, but I would be more comfortable taking the leap if there were more data published, or some additional investigational drugs in development. IMHO ACC