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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?


To: blankmind who wrote (9701)6/16/1998 7:53:00 AM
From: OmertaSoldier  Read Replies (2) | Respond to of 23519
 
Tuesday June 16, 7:29 am Eastern Time

Company Press Release

Vivus' MUSE, Alprostadil, Achieves 60% Efficacy in
Diabetic Men

Data Presented At the ADA Meeting in Chicago

MOUNTAIN VIEW, Calif.--(BW HealthWire)--June 16, 1998--VIVUS, Inc. (NASDAQ:VVUS
- news) today announced the results of an independent study in which MUSE(R) (alprostadil)
achieved a 60% efficacy rate in diabetic men with erectile dysfunction. The abstract was presented
at the American Diabetes Association annual meeting in Chicago which concluded today.

The 230 person study included 65 diabetic and 165 non-diabetic men with erectile dysfunction who
received MUSE for up to six months. Prior to MUSE dosing, patients had a 30-45 minute
counseling session that included a video on the proper administration of MUSE. The treatment was
deemed successful when patients completed sexual intercourse on two or more occasions. The
researchers reported that 60% of the diabetic patients had ''success'' compared to 54% of
non-diabetic patients. It is estimated that half of the approximately four million men with diabetes
mellitus in the United States will experience erectile dysfunction.

''MUSE is a good treatment option for men with diabetes and/or vascular disease especially
because it has few systemic side effects,'' said Kenneth Snow, MD, Medical Director of the
Joslin-Lahey Diabetes & Endocrinology Center in Peabody, MA and a lead investigator in this trial.
The authors also concluded that MUSE appears to be more effective in men over the age of 50 and
perhaps more effective in men with organic risk factors, as opposed to psychological factors.
Approximately 80% of all cases of erectile dysfunction are believed to have a physiological origin.
The investigators also noted that patient education is critical to the success of the treatment.

''This is an important new trial that confirms the efficacy of MUSE in treating erectile dysfunction
during actual clinical practice,'' stated Leland Wilson, President and Chief Executive Officer. ''The
rate of effectiveness reported here equals or surpasses what we have seen in previous studies. In
addition, the trial demonstrates that education is key to the successful use of MUSE.''

Founded in 1991, VIVUS, Inc. is a leader in the development of advanced therapeutic systems for
the treatment of erectile dysfunction, commonly referred to as impotence. VIVUS has pioneered a
novel therapy for erectile dysfunction known as MUSE Note to editors: MUSE is a registered
trademark of VIVUS, Inc. Additional written materials, recent releases and Company information
are available through a variety of sources, including: the VIVUS home page (www.vivus.com) and
the VIVUS Fax-On-Demand Service (1-888-329-5719).

Contact:

VIVUS
Nina W. Ferrari, 650/934-5200