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Biotech / Medical : QuestCor QSC -- Ignore unavailable to you. Want to Upgrade?

To: roy whitt who wrote (91)	6/24/1998 3:07:00 AM
From: Philip Aaron Etttedgui	Read Replies (1) \| Respond to of 120

Cypros derives its name from the term "Cyto" (meaning cell) and the word "protective". This name is entirely appropriate as it describes the key property of Cypros' drugs--they protect living cells from harm. Both Ceresine and Cordox, protect cells from damage caused by oxygen depletion. What's more is that Cordox, in particular, has also been shown to protect cells from other insults--not just ischemia. These insults include the toxic effects of several drugs used in medicine today. For example, one of the most lethal drugs on the market today happens to be acetaminophen, the active ingredient in Tylenol. While it is very safe in low doses, higher doses (>4g/day) cause hepatocel- lular necrosis, which can lead to liver failure and death. A few years ago a study was published by one of the foremost authorities on fructose diphosphate (Cordox) pharmacology, Dr., A. K. Markov, in which rats were subjected to acetaminophen poisoning and were given Cordox. That study demonstrated that fructose diphosphate attenuated acetaminophen-induced liver injury and did so by promoting nitric oxide release/synthesis--a key intermediate necessary for normal microcirculation. (Gastroenterology, v.108, n.4 SUPPL.,(1995): A1122.) Another example of a toxic drug Cordox protects against is the widely used immunosppressive agent, cyclosporine. This drug is used to prevent rejection of transplanted organs. One of the drug's side effects, however, is cardiomyopathy, which can eventually lead to heart failure. In another study conducted by Markov, cordox was shown to attenuate the myocardial toxic effects of cyclosporine in vitro. (Research Communications in Molecular Pathology and Pharmacology, v.89, n.1, (1995): 17-26) Cyclosporine is also toxic to the kidneys and yet another study has shown that cordox protects the kidneys from cyclosporine insult (Nephron, v.72, n.1, (1996): 67-71). Moreover, in animals cordox has also been shown to enhance cyclosporine's ability to promote graft survival, while at the same time protecting the heart and kidneys from cyclosporine's deleterious effects (European Heart Journal, v.15, n.ABSTR. SUPPL., (1994): 277.) Another nasty drug is the antifungal agent, amphotericin. This drug is so toxic it has been often referred to as "amphoterrible" The drug causes cardiomyopathy as well as acute renal failure. Preliminary evidence from an in vitro study condcted by Markov suggests that Cordox can reverse/attenuate the myocardial toxic effects of ampho-B. (Biochemistry and Molecular Biology International, v.37, n.5, (1995): 821-825.) The same may also be true for the once popular drug of abuse, yet cardio-toxic drug, phencyclidine (PCP). This drug damages the heart by blocking an enzyme in the heart tissue, a calcium ATPase and Cordox reverses this blockage (Research Communications in Alcohol and Substances of Abuse, v.17, n.1-2, (1996): 49-56.) While these studies are all "pre-clinical"--not involving humans, they do point to a remarkable property this drug has in living tissue: it protects and preserves cells from injury and harm. Because the drug has been shown to be unusually safe, there is a reasonable likelihood that this drug may be used in such areas as acetaminophen overdose, as well as an adjunct to amphotericin and to cyclosporine. --Drug Doc