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Biotech / Medical : VD's Model Portfolio & Discussion Thread -- Ignore unavailable to you. Want to Upgrade?

To: lwd who wrote (5127)	6/17/1998 2:57:00 PM
From: Rocketman	Respond to of 9719

Synteni has access to the INCY DNA banks for source material, which is something AFFX doesn't have. It seems to me that it should be cheaper for Synteni to spot DNA down than to build it up on the chip like AFFX does. Synteni's method I'm sure is automated, this is not a hand process. It's been 15 years since I personally hybridized DNA, but the longer the probe, the more specific it can be. Basically this comes down to the odds of having a specific 20 bp sequence being repeated in many genes, versus the odds of a 1000 bp sequence being repeated. As far as the better way to find SNPs, I'm not at all sure. INCY finds a lot of SNPs just in the sequencing itself. My gut feeling guess is that the longer the probe the better for finding SNPs, but I'm not totally sure on the point. Any hybridization experts out there, we'd love to hear from you. Rman