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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: WTDEC who wrote (22506)6/18/1998 11:33:00 PM
From: Henry Niman  Read Replies (2) | Respond to of 32384
 
Walter, It sounds like much of the initial results in the abstract are in the cell culture area. Although I don't have first hand knowledge of the Dunning rat model, he xenografts are almost certainly human tumors that respond to treatment with the anti-androgen. It sounds like LGND is getting ready to file and IND later this year, and I suspect that the excellent preclinical data sets the stage for some successful clinicals. It also sounds like the new compounds have excellent specificity, which theoretically would lead to better clinical results.



To: WTDEC who wrote (22506)6/19/1998 6:00:00 AM
From: Henry Niman  Read Replies (1) | Respond to of 32384
 
Looks like MRK and Astra have reached a restructuring agreement:

The Wall Street Journal -- June 19, 1998
Technology & Health:

Merck, Astra Reach
Restructuring Pact

---
Swedish Firm Would Gain
Ownership of Venture,
Still Provide Royalties
----

By Steven Lipin and Robert Langreth
Staff Reporters of The Wall Street Journal

Merck Co. and Sweden's Astra AB expect to announce that they have
reached a definitive agreement over restructuring their longstanding joint
venture, a move that could provide Merck with billions in cash while giving
Astra control, according to people familiar with the matter.



To: WTDEC who wrote (22506)6/19/1998 6:02:00 AM
From: Henry Niman  Respond to of 32384
 
CNBC just mentioned the MRK/Astra restructuring and ZEN is up in anticipation (and Bayer has also been mentioned as a potential Astra partner):
Dow Jones Newswires -- June 18, 1998
Zeneca Shares Jump As Astra Merger Talk Resurfaces

LONDON (Dow Jones)--Shares in Zeneca Group PLC (ZEN) have
jumped higher Thursday on fresh speculation over a possible merger with
Sweden's Astra AB (A), analysts said.



To: WTDEC who wrote (22506)6/19/1998 6:05:00 AM
From: Henry Niman  Respond to of 32384
 
Story is also being carried by Reuters:http://biz.yahoo.com/finance/980619/merck_mrk__2.html
Friday June 19, 4:48 am Eastern Time

Merck ,Astra reach new deal - WSJ

NEW YORK, June 19 (Reuters) - Merck & Co. Inc. (MRK - news), and Astra AB (ASTRa.ST) are expected to announce
they have reached a definitive agreement over the restructuring of their long-standing joint venture Astra Merck Inc., the
electronic edition of the Wall Street Journal reported on Friday.

Citing people familiar with the deal, the Journal said the move could provide Merck with billions in cash while giving Astra
control over the Wayne, Pennsylvania-based Astra Merck business.



To: WTDEC who wrote (22506)6/19/1998 9:34:00 AM
From: Henry Niman  Respond to of 32384
 
Astra/MRK have now put out a press release on the restructuring:

ASTRA AND MERCK RESTRUCTURE ASTRA MERCK
RELATIONSHIP

PR Wire
June 19, 1998, 5:28 a.m. PT

-- New Entity, Astra Pharmaceuticals, to Combine

Operations of Astra Merck and Astra USA

-- Astra to Assume Management Control of Astra Pharmaceuticals

-- Astra Expects Combination to Generate Significant Synergies

-- Merck to Participate in Astra Pharmaceuticals' Growth

-- Agreement Accretive to Merck Immediately; to Astra After Two Years

-- Astra Acquires Right to Buy Out Merck's Interest in 2008 at Earliest

NEW YORK, June 19 /PRNewswire/ -- Astra AB (NYSE: A) and Merck & Co.,
Inc. (NYSE: MRK) announced today they have signed a definitive agreement under
which their 50-50 joint venture, Astra Merck, Inc., will be restructured and
Astra Merck's business will be combined with Astra's wholly owned subsidiary,
Astra USA Inc., in a new U.S. limited partnership, named Astra Pharmaceuticals
LP, over which Astra will have management control as the general partner.

Astra expects that the combination of Astra Merck and Astra USA and the
resultant opportunities to market products of both entities more effectively,
will create revenue synergies. While Astra anticipates no reduction in the
field sales forces, it does expect that Astra Pharmaceuticals will benefit
from cost savings in other areas of about $100 million annually by 2000.
Astra expects the restructuring of the relationship with Merck to be accretive
to Astra Group net earnings from 2000 after a modest initial dilution.

Merck expects that from the outset the new agreement will yield more
revenue and income to Merck than the company would have received under the
existing joint venture agreement. Under the new agreement, Merck will receive
financial consideration in three ways: First, Merck will receive ongoing
revenue and income for at least 10 years based on sales of current and
pipeline Astra Merck products and certain Astra USA products. Second, Astra
will have the right to buy out Merck's interest in these products in 2008,
2012 or 2016, except that Merck's interest in the gastrointestinal medicines
Prilosec and perprazole will continue until 2017, if their combined sales stay
above a specified level. The cash buyout will be based on a multiple of the
prior three-year average of pre-tax income received by Merck for all products
except Prilosec and perprazole, but will be no less than $4.4 billion in 2008.
Third, in order to facilitate the restructuring, Astra will loan Merck
$1.4 billion in cash at closing.

In addition, if Astra merges with or is acquired by another company, Merck
will continue to receive ongoing revenue and income from sales of then current
and pipeline products, but Merck's right to revenue and income from compounds
subsequently discovered or acquired will terminate and Merck will receive a
payment of $675 million to $1.5 billion. In this event, Merck could require
Astra, in 2008, to purchase Merck's interest in sales of then current and
pipeline products (except Prilosec and perprazole), but the minimum received
by Merck will be higher than it would have been had Astra not merged or been
acquired.

The newly-formed entity, Astra Pharmaceuticals, will have headquarters in
Wayne, PA, with production and development facilities in Westborough, MA.
Astra Pharmaceuticals will be fully consolidated into Astra Group's
financials. On a pro forma basis, Astra Pharmaceuticals had 1997 sales of
approximately $2.7 billion, which represents approximately 40 percent of Astra
Group sales, and 3,800 employees. Carl-Gustaf Johansson will be President and
CEO of Astra Pharmaceuticals. Mr. Johansson is an Executive Vice President
and member of executive management of Astra Group. He will retain those
responsibilities.

"This transaction establishes a new and more dynamic presence for Astra in
the United States," said Hakan Mogren, Astra President and CEO. "The strength
of our product portfolio and our R&D pipeline will be complemented and
enhanced by the efficiency and critical mass resulting from the creation of
Astra Pharmaceuticals. Astra today embarks on the next stage in our growth
and development. We now have the strategic freedom to best serve the
interests of our shareholders by charting our own course in the global
pharmaceutical market."

Raymond V. Gilmartin, Merck Chairman and CEO said: "The new arrangement
offers multiple benefits to Merck in terms of our long-term growth objectives.
Merck's share in the profitability of the current and pipeline Astra Merck
products, including Prilosec, will be undiminished and Merck will gain
additional income from certain Astra USA. products. Moreover, Merck will
receive full value for its interest in Astra's pipeline should Astra merge or
be acquired or should Astra exercise its option to buy out Merck's interest in
2008 or beyond. All in all, this is a very advantageous agreement for Merck
shareholders at this juncture."

Judy C. Lewent, Merck Senior Vice President and CFO said: "Over the
years, the Astra Merck joint venture has contributed to Merck's growth. We
are pleased that, through this new agreement, Merck will participate in the
future growth of Astra Pharmaceuticals."

"The exceptional growth of Astra Merck and Astra USA has come as a result
of the dedication of employees at both companies. Based on the portfolio of
current products from both Astra Merck and Astra USA and the pipeline of
planned introductions over the coming years, we believe Astra Pharmaceuticals
will be able to offer our employees exciting and challenging career
opportunities," Mr. Mogren concluded.

Astra and Merck began their collaboration in 1982 and commenced their
50-50 joint venture, Astra Merck in 1994. Astra Merck markets certain Astra
products in the U.S., including Prilosec, the best-selling prescription
medication in the world. Astra Merck, which had 1997 sales of $2.3 billion,
has 2,200 employees, including a 1,500-person sales force. Astra USA
established in 1947 and located in Westborough, MA, is a leading marketer of
hospital products in the U.S., including Xylocaine, a leading local
anesthetic. Astra USA which had 1997 sales of $400 million, has approximately
1,600 employees, including a 700-person sales force. In recent years, the
company has successfully introduced several products in the U.S. market,
including Toprol-XL, a beta-blocker, and is at present introducing Pulmicort
Turbuhaler, the biggest-selling anti-asthma agent in Europe.

Astra and Merck anticipate no impediments to closing the agreement as of
July 1, 1998, and will work together to effect an orderly transfer to Astra's
control. No Hart Scott Rodino anti-trust filing is required for this
transaction.

Astra is an international pharmaceutical company, based in Sweden, with
operations in some 45 countries. The company, a leader in the development of
gastrointestinal, cardiovascular, respiratory and pain control products with
1997 revenues of $5.9 billion, has been one of the fastest-growing
pharmaceutical companies over the past decade.

Merck is a global, research-driven pharmaceutical company that discovers,
develops, manufactures and markets a broad range of human and animal health
products, directly and through its joint-ventures, and provides pharmaceutical
benefit services through Merck-Medco Managed Care.

This press release contains "forward-looking statements," as that term is
defined in the Private Securities Litigation Reform Act of 1995.

The forward-looking statements by Merck are related to expectations of the
effect on Merck's revenue and income as a result of the new agreement. No
forward-looking statement can be guaranteed and actual results may differ.
Additional, detailed information concerning a number of factors that could
cause actual results to differ materially is set forth in Merck's Form 10-K
(under "Cautionary Factors That May Affect Future Results") for the fiscal
year which ended December 31, 1997. Copies of Merck's Form 10-K are available
on request to Merck's Office of Stockholder Services.

The forward-looking statements by Astra are related to projections about
operating and financial results as a result of the new agreement. No
forward-looking statements can be guaranteed and actual results may differ
materially from those indicated as a result of various important factors.
Additional, detailed information concerning certain such factors and other
risks are set forth in Astra's filings with the Securities and Exchange
Commission, including its annual report on Form 20-F for the fiscal year ended
December 31, 1997. A copy of Astra's Form 20-F is available upon request to
Astra's Office of Investor Relations.
SOURCE Astra AB; Merck & Co., Inc.

-0- 06/19/98

/NOTE TO EDITORS: Prilosec, Toprol-XL, Xylocaine and Pulmicort Turbuhaler
are registered trademarks./

/CONTACT: Staffan Ternby, press, 46-8-553-261-07, Michael Olsson,
investor relations, 46-8-553-259-52, or Jorgen Winroth, investor relations
U.S., 609-896-4148, all of Astra AB; or John Doorley, press, 908-423-4081, or
Laura Jordan, investor relations, 908-423-5185, both of Merck & Co./

(A MRK)
CO: Astra AB; Merck & Co., Inc.
ST: New York
IN: MTC
SU: