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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?

To: DaiS who wrote (3843)	7/1/1998 9:54:00 AM
From: Perry	Read Replies (1) \| Respond to of 9523

<<Well I have to admit that I have not seen nor studied the Pfizer reports to the regulators, but I think that the scientific publications to not provide information as to whether interactions involving the group categorisations are significant or not - correct me if I am wrong. I would like to see and have time to study the full evidence.>> When PFE originally got FDA approval there was a detailed report regarding the clinical results for Viagra on, I believe, the FDA site. I unfortunately do not have the report. Can somebody else possibly steer DaiS in the right direction? <<On this specific point, there is alternative non-statistical approach. You can take each man that has died, do an autopsy and a scientific investigation of this individual to establish precisely why he died - a mechanistic approach for this individual.>> I would be very surprise if autopsies were not conducted on at least some of the individuals that have died. I am not a coroner but I assume that any suspicious death(s) is examined in this way. In fact I recall that autopsies were done on some individuals and nothing was found to suggest a causal link to Viagra. <<The approach could involve theoretical considerations of the effect of the drug given it's structure - is it a poison - and so on.>> If your talking about overt toxicity in the form of liver necrosis etc.. I don't think Viagra has ever been implicated as a cytotoxic agent, as evidenced by increases in blood liver enzyme (ALT etc..) levels. I still think the numbers speak for themselves and continue to support Viagra as a safe and efficacious drug that is obviously helping 10000s of men. Perry

To: DaiS who wrote (3843)	7/1/1998 3:52:00 PM
From: Saul H Rosenthal	Read Replies (1) \| Respond to of 9523

Dais, For every million men over 60-80 probably several hundred die every month, at least. That means that, since close to 2 million men have taken Viagra for a couple of months, there have probably been at least 200-300 deaths of men on Viagra. Only 30 or so have been reported. That is a remarkably SMALL number for the age of the men and the number. If 100 deaths had been reported it wouldn't mean a thing considering the age and size of the patient population. Saul