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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Tharos who wrote (6621)	7/4/1998 5:55:00 PM
From: Robert K.	Respond to of 17367

According to One investigator in Lancet, bpi is almost totally not seen by anca to BPI. therefore bpi21 may be quite useful.

To: Tharos who wrote (6621)	7/4/1998 8:17:00 PM
From: Robert K.	Read Replies (2) \| Respond to of 17367

From the Lancet>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> >>". Although the occurrence of autoantibodies against BPI (BPI-ANCA) has been reported in vasculitis, cystic fibrosis, and inflammatory bowel disease2-4 the frequency of BPI-ANCA in patients with gram-negative sepsis has not been recorded so far.............."Missing"................. These antibodies did not recognise the amino-terminal fragment of rBPI21 on testing. Furthermore, analysis of 96 patients with BPI-ANCA revealed only two whose BPI-ANCA recognised rBPI21; however, the underlying disease in these patients was not sepsis but vasculitis and inflammatory bowel disease.5 ..................... Taken together BPI-ANCA were not detected in gram-negative sepsis in noteworthy amounts, and if detected they do not bind to the N-terminal fragment of BPI. Thus the use of rBPI21 in patients with gram-negative sepsis is probably not limited by generation of autoantibodies against BPI. Hendrik Schultz, *Elena Csernok, Wolfgang L Gross >end abbreviated lancet< Moral of the story is anca to bpi "may" not "see" bpi21. All disclaimers always apply. All IMO,(and others)