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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?

To: Tunica Albuginea who wrote (3916)	7/4/1998 3:13:00 PM
From: Brander	Read Replies (2) \| Respond to of 9523

" In the long term this continued stimulation of the retina can cause premature retinal degeneration and blindness." I don't believe there is any evidence supporting that statement. If it were true, Viagra would have been pulled by now. In fact, if that statement was true, Viagra would have never been approved by the FDA. The inhibition of PDE6 was well known about prior to FDA review and approval.

To: Tunica Albuginea who wrote (3916)	7/4/1998 8:10:00 PM
From: DaiS	Respond to of 9523

>>At this higher dose, even though Viagra is a selective PDE5 inhibitor,it now becomes non-selective, like every other known phosphodiesterase inhibitor, and starts inhibiting PDE6 in the retina thus causing the blue vision>> No Tuna you are wrong. Sildenafil is more selective for PDE6 - see Pfizer web site. >>Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina; this lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels>> pfizer.com DaiS