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Biotech / Medical : SANGUINE CORP. (SGNC) -- Ignore unavailable to you. Want to Upgrade?

To: Dixie7777 who wrote (2871)	7/8/1998 11:27:00 PM
From: Prospector	Respond to of 5402

Do we know who the "investor" is that gave the money to SGNC for the battelle testing? YES Prospector

To: Dixie7777 who wrote (2871)	7/8/1998 11:43:00 PM
From: Prospector	Respond to of 5402

where'd ya go dixie... What kind a fish ya got down south... prospector...

To: Dixie7777 who wrote (2871)	7/9/1998 1:38:00 AM
From: chirodoc	Read Replies (1) \| Respond to of 5402

pfc's IMPROVE lung function in animals and don't gloss over this sentence: " The procedure was tolerated well by the animals." ...phase I, II trials here we come! J Formos Med Assoc 1998 Jun;97(6):392-399 Liquid ventilation for treatment of meconium aspiration syndrome in a piglet model. Kuo CY, Hsueh C, Wang CR Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan. [Medline record in process] We tested the hypothesis that liquid ventilation (LV) with perfluorocarbon (PFC) can remove aspirated meconium and improve lung function in experimental meconium aspiration syndrome (MAS). PFC (FC-77) was used as the medium in LV. Sixteen piglets were divided into control and LV groups (8 animals/group). All animals received slurry meconium (20% in normal saline) via endotracheal instillation at baseline. Thirty minutes later, the LV group received 15 cycles of LV. Pulmonary mechanics, arterial blood gases, and hemodynamic values were recorded at baseline, and 30, 60, 120, 180, and 240 minutes after meconium instillation. Chest radiographs and lung sections were taken and scored at the end of the study. The percentage of meconium cleared by LV was calculated as the ratio of the dry weight of washings to that of meconium instilled, multiplied by 100. The procedure was tolerated well by the animals. LV cleared 25% +/- 7% of the instilled meconium. Tidal volume (9.5 +/- 2.0 vs 7.1 +/- 0.8 mL/kg, p = 0.012), respiratory system compliance (2.32 +/- 0.60 vs 1.60 +/- 0.24 mL/cmH2O, p = 0.01), PaO2 (65 +/- 7 torr vs 55 +/- 6 torr, p = 0.0067), and arterial to alveolar oxygen ratio (0.14 +/- 0.01 vs 0.12 +/- 0.01, p = 0.0077) were improved in the LV group at 60 minutes after meconium instillation compared with those of the control group. The scores of exudative debris (1.7 +/- 0.3 vs 2.1 +/- 0.2) and visible meconium (1.4 +/- 0.5 vs 2.1 +/- 0.5) were significantly lower in the LV group. In conclusion, short-term L.V with FC-77 can partially remove aspirated meconium from the lungs and improve pulmonary function transiently.