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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (6659)	7/13/1998 2:45:00 PM
From: Robert S.	Read Replies (3) \| Respond to of 17367

<< I never thought BPI bound up all endotoxin. This is dead material and it is not reproducing. The body may/will remove some with its own host defenses and while the remaining endotoxin will do damage I thought that it would be reduced relative to the amount that would have occurred in none was bound up and eliminated by BPI.>> While my colleagues and I are interested in the BPI molecule, statements such as yours raise doubts about BPI. Please correct me if I am wrong, but aren't endotoxins poisonous byproducts of dead gram-negative bacteria? Since bacteria can and do evolve, sometimes very rapidly, to changes in their environment, does this not suggest that the gram-negative bacteria that survives BPI can evolve and eventually flourish as it passes on these traits to it's (so to speak) offspring ?