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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: Zebra 365 who wrote (11657)	7/16/1998 11:14:00 PM
From: VLAD	Read Replies (1) \| Respond to of 23519

Zebra, Thanks for the correction. Sometimes I just get carried away with my zer000000000000000000000000000000s.

To: Zebra 365 who wrote (11657)	7/17/1998 12:11:00 AM
From: AlienTech	Respond to of 23519

Yea well they were old farts, They deserved to die for having sex or even thinking about it. In fact its a proven fact that Viagra is much much safer than your average rat poison.

To: Zebra 365 who wrote (11657)	7/17/1998 7:47:00 AM
From: Stitch	Respond to of 23519

Zebra, <<New Study Demonstrates Long-Term Safety of VIVUS' MUSE>> Thats' what I was looking for. Many thanks. best, Stitch

To: Zebra 365 who wrote (11657)	7/17/1998 8:22:00 AM
From: DaiS	Read Replies (1) \| Respond to of 23519

Zebra, Vlad, The abstract below is also by JD Engel who was co-author the Urology muse study press released yesterday. I do not really understand the abstract but does it give any clue regarding the Vivus incontinence work? DaiS TI: Surgical versus endoscopic correction of vesicoureteral reflux in children with neurogenic bladder dysfunction AU: Engel_JD, Palmer_LS, Cheng_EY, Kaplan_WE NA: NORTHWESTERN UNIV,SCH MED,CHILDRENS MEM MED CTR,DIV UROL,CHICAGO,IL,60611 JN: JOURNAL OF UROLOGY, 1997, Vol.157, No.6, pp.2291-2294 IS: 0022-5347 AB: Purpose: We attempted to compare the efficacy of subureteral polytetrafluoroethylene injection and ureteral reimplantation for treating vesicoureteral reflux in children with neurogenic bladder dysfunction. Materials and Methods: We retrospectively studied the records of all children with neurogenic bladder dysfunction and reflux into single collecting systems treated with cross-trigonal ureteroneocystostomy or subureteral polytetrafluoroethylene injection. Followup cystography was performed 2 months postoperatively and ultrasound was done twice yearly thereafter. Urodynamic data were evaluated when available. Success was defined as complete eradication of reflux. Data were stratified by procedure, patient sex, grade and laterality of reflux, and the presence of unilateral or bilateral reflux, and then compared using chi-square analysis. Results: Of 85 patients (118 ureters) identified followup data were available in 95%. Subureteral polytetrafluoroethylene injection and ureteroneocystostomy were done an 60 and 47 ureters, respectively. Both groups were similar in mean patient age, followup and preoperative degree of reflux. Success rates after ureteroneocystostomy and a single injection were 84.3 versus 56.7%. The cumulative success rate of subureteral polytetrafluoroethylene injection was 61% after a second injection. The success rate of ureteroneocystostomy was significantly greater than that of injection (p = 0.02). Reflux resolved in all patients in whom injection failed and who underwent secondary reimplantation. Successful ureteroneocystostomy was unrelated to patient sex, reflux grade or laterality, or bilateral versus unilateral reflux. Subureteral polytetrafluoroethylene injection was more likely to fail in higher grades of reflux (p = 0.03) but success was otherwise unrelated to other parameters. Failure to correct reflux was unrelated to urodynamic findings. Conclusions: Primary open ureteral reimplantation is more effective than subureteral polytetrafluoroethylene injection for correcting reflux in children with neurogenic bladder dysfunction. Despite controversy related to the appropriate injectable substance, the relative technical simplicity, outpatient nature, rapid recovery and potential for successful secondary reimplantation support a role for subureteral polytetrafluoroethylene injection in managing reflux in these difficult cases. KP: POLYTETRAFLUOROETHYLENE INJECTION, MANAGEMENT, EXPERIENCE WA: vesico-ureteral reflux, ureter, meningomyelocele, polytetrafluoroethylene, endoscopy