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To: Patricia Trinchero who wrote (1236)	7/20/1998 1:13:00 PM
From: firstman	Respond to of 4028

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells Science, Jan 16, (1998). Andrea G. Bodnar, Michel Ouellette, Maria Frolkis Shawn E. Holt, Choy-Pik Chiu, Gregg B. Morin, Calvin B. Harley, Jerry W. Shay, Serge Lichtsteiner, Woodring E. Wright Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this hypothesis, two telomerase-negative normal human cell types, retinal pigment epithelial cells and fore-skin fibroblasts, were transfected with vectors encoding the human telomerase catalytic subunit. In contrast to telomerase-negative control clones, which exhibited telomere shortening and senescence, telomerase-expressing clones had elongated telomeres, divided vigorously, and showed reduced staining for b-galactosidase, a biomarker for senescence. Notably, the telomerase-expressing clones have a normal karyotype and have already exceeded their normal life-span by at least 20 doublings, thus establishing a causal relationship between telomere shortening and in vitro cellular senescence. The ability to maintain normal human cells in a phenotypically youthful state could have important applications in research and medicine. could have? That's the understatement of the century!

To: Patricia Trinchero who wrote (1236)	7/20/1998 3:11:00 PM
From: Nancy McKinney	Read Replies (2) \| Respond to of 4028

Pat, Well, by the time they get this done, and it's marketable, all us baby boomers will have wrinkles, age spots, and sagging places (not that we don't already!). Will we need our codes changed with shots or pills to look younger? :>) Will it be cheaper than cosmetic surgery? Less risky? Wonder how long it will take to see the results of the genetic codes delivered to my cells? What if the virus doesn't know when to stop? Will I have a childish face? Will I look young in places and old in others? I have some good night cream that works overnight, but then my wrinkles always come back! MOre I think about it, this new technology may take a while to "perfect". Hope all you longs are ready to hold. I'm not bashing, just thinking. I still have my position while I think. Think not only about the good possibilities, but the challenges, too. Nancy