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Biotech / Medical : Ionis Pharmaceuticals (IONS) -- Ignore unavailable to you. Want to Upgrade?

To: Sonny who wrote (2131)	7/23/1998 2:06:00 AM
From: tom jones	Read Replies (3) \| Respond to of 4676

To all: The fda approval does not mean that antisense technology works. In fact Isis could not show that antisense was taking place with their drug ISIS 2922. ISIS 2922 was injected locally so it did not have to travel through the body where it could be destroyed. If antisense is working here (which I hope it is) there is still a very big problem of getting the drug to where it is needed in other uses. Antisense will only be proven after they show that a few more drugs work which will take a couple more years. Tom

To: Sonny who wrote (2131)	7/23/1998 2:18:00 AM
From: David Shie	Respond to of 4676

"What gives" may be from investors like myself who have never heard of this company (nor its attractive potential) until tonight while reading the daily summary from Briefing.com... This company sounds like it certainly has some potential. Not too familiar with pharmaceuticals, so am wondering what near-term potential upside this stock may have. David

To: Sonny who wrote (2131)	7/23/1998 9:25:00 AM
From: Scott H. Davis	Read Replies (2) \| Respond to of 4676

Thought: Either everbody needs to be given access to after hours trading, or nobody should have access. Individual investors who do a lot of DD are not given the opportunity to use that background in cases like this. The big question in terms of ability to hold is whether the market collectively judges that the technology platform has just been validated. My call is we'll get partial acceptance, meaning some reduced volitility after the innevitable swings the next few days. A positive phase III for a systemic may be needed for the market to collectively give "two thumbs up" IMSCO Scott One thing I forgot to mention yesterday is that if my memory is correct, yesterday may trigger a milestone payment, or is that not until the FDA gives final approval? (the gray cells are challenged this A.M as they have not received their initial loading dose of caffine yet)