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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (6800)	7/26/1998 9:37:00 AM
From: Robert K.	Respond to of 17367

The bodies OWN bpi sepsis clinical test >>>>>>>>>>>>>>>>>>>>>>> >Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome. Wong HR, Doughty LA, Wedel N, White M, Nelson BJ, Havrilla N, Carcillo JA Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA. Bactericidal/permeability-increasing protein (BPI) is a neutrophil azurophilic granule component that is bactericidal towards Gram-negative bacteria and inhibits lipopolysaccharide-mediated inflammatory responses. We conducted a prospective study to measure plasma BPI concentrations in 36 critically ill children with and without the sepsis syndrome. Plasma BPI concentrations ranged from 0.5 to 452 ng/ml. Patients with the sepsis syndrome had higher median plasma BPI concentrations than critically ill controls (5.1 vs. 1.8 ng/ml, P = 0.006). Patients with organ system failure had higher median plasma BPI concentrations than those with no organ system failure (4.5 vs. 1.3 ng/ml, P = 0.001). Plasma BPI concentrations were positively associated with pediatric risk of mortality score (P = 0.03, rs = 0.4). These data provide the first clinical insights regarding the role of endogenous BPI production in critically ill children and suggest that BPI may play an important role in host defenses. <<END My question> Why does the human body use bpi as defense to sepsis? Must be some reason. Hmmmmmmmmm.