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Biotech / Medical : Cancer, biotechs fight against it -- Ignore unavailable to you. Want to Upgrade?

To: James Y. who wrote (3)8/8/1998 4:38:00 PM
From: Mike K  Read Replies (1) | Respond to of 10
 
Jim;

It's my understanding, that animal models (particularly mice) can provide an indication of the response rate in humans. The response model is different for different types of cancer. Mice are used because they are cheap and with the short reproductive cycle, successive generations can be studied.

I really can't give you a better answer because any of the researchers
that I have talked to are also vague.

I'm very interested in the work that SUGN is doing on angiogenesis
inhibitors.

Cheers,

Mike



To: James Y. who wrote (3)8/17/1998 7:55:00 PM
From: seminole  Respond to of 10
 
James

The limitations of the mice model are presented
in Science Vol. 278, Nov. 7,1997 : Systems for Identifying
New Drugs are Often Faulty.

When looking at the mice model, make sure the tumor
cell line is aggressive. They need to provide a strong test
for their drug. (I look for cell lines that are used in the
NCI's 60 cell line screen.)

So far a strong model has helped get MOGN to Phase II trials.
Good Luck,
richard


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