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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?


To: Mkilloran who wrote (5623)9/19/1998 11:02:00 AM
From: Anthony Wong  Read Replies (1) | Respond to of 9523
 
With this Muse, erections are a pill away

SEP 19 1998
The Straits Times


By LEA WEE

A NEW way to deliver a drug to help impotent men get an erection will
be launched officially today at the Asian Congress of Urology.

Muse (Medicated Urethral System For Erection) involves inserting a
pellet containing the drug alprostadil into the urethra in the penis.

Previously, doctors had to use a syringe to inject the drug into the
penis.

Muse has been tried by about 100 impotent men in Singapore in an
ongoing trial that started in January this year.

Early results show that six out of every 10 men had an erection within
minutes. The erection would last for about 30 minutes to an hour.

About 3 per cent of the men had minor side effects. They included
aching in the penis and groin, dizziness, flushing and minor bleeding due
to improper administration.

These results are comparable to those elsewhere, said National
University Hospital urologist Li Man Kay, who will present the findings
at the congress today.

The men studied are from the Singapore General Hospital, NUH, Tan
Tock Seng Hospital and the New Changi Hospital.

The drug alprostadil is similar to a naturally-occurring substance in
human semen which opens up blood vessels to increase the blood flow
to the penis to cause an erection. It has been used to treat impotence
for the last six to seven years and is safe and effective, said urologist
Peter Lim from the Changi General Hospital.

Dr Li added that unlike Viagra, alprostadil can be used for patients with
heart problems, renal or liver failure.

While Viagra causes an erection only when a man is stimulated sexually,
alprostadil does not require any mental stimulation for the blood to rush
to the penis.

Said Dr Lim: "Thus, it works better for patients with very bad blood
flow, for instance, patients with severe diabetes, or paraplegics."

But the doctors cautioned that Muse was not suitable for all impotent
men.

Such men would include those who are hypersensitive to alprostadil,
have an abnormally-formed penis, or who have conditions that might
result in long-lasting erections, such as sickle cell anaemia, leukaemia or
tumour of the bone marrow.

straitstimes.asia1.com.sg



To: Mkilloran who wrote (5623)9/19/1998 11:06:00 AM
From: Sonki  Respond to of 9523
 
Re: death of a man who is NOT taking nitrates and PFE's response.
------------------------------------------------
A Dutch man suffered a heart attack 30 minutes after taking the PFIZER INC's
anti-impotence pill Viagra even though he had no medical condition that could
cause adverse reactions to the drug, doctors said. The doctors, from the
Inspectorate of Health Care in the Netherlands, reported the incident in a letter
in The Lancet medical journal published three days after the pill was approved
for use in Europe. The 65-year-old man was not taking nitrates, had no history
of heart or liver problems, high blood pressure or diabetes, never smoked and
was a moderate drinker.

_____

Pfizer response

PFIZER INC. said there was no evidence that its impotence drug Viagra caused
heart attacks or strokes. In response to a letter sent by doctors to the Lancet
magazine outlining the case of a 65-year-old Dutch man who died 30 minutes
after taking the drug, Pfizer said: "To date over three mln men have been
prescribed approximately 35 mln Viagra tablets. This experience provides a
consistent picture of the safety of Viagra when used appropriately." Pfizer noted
the doctors writing in the Lancet stated it was unclear to what extent
pre-existing coronary artery disease may have contributed to the onset of a
heart attack in the patient. (Reuters 07:07 AM ET 09/18/98)



To: Mkilloran who wrote (5623)9/19/1998 11:06:00 AM
From: Anthony Wong  Respond to of 9523
 
Asian task force to tackle impotence
The Straits Times, SEP 19 1998


A NEW all-Asian task force was announced yesterday to tackle
erectile dysfunction. The problem is estimated to affect about half the
men in Asia aged 40 to 70.

The Erectile Dysfunction Advisory Council and Training (Edact) is
made up of doctors from hospitals and clinics in 11 countries in the
Asia-Pacific region.

It will develop programmes to help improve public awareness and
doctors' understanding and management of impotence.

The Edact chairman, Professor Hyung-Ki Choi from South Korea, said
that it is "a tragedy that many men suffer in silence because they are too
embarrassed to seek help".

He said about nine out of 10 men with erectile problems do not see the
doctor.

He added: "Many cases remain undiagnosed because both doctors and
patients are reluctant to discuss sexual function."

Also, awareness among doctors is generally low on what to look for
and how to treat impotence.

An Asian Edact website, (http://www.asianedact.org.hk) was also
launched yesterday. It provides information on impotence for both
doctors and patients.

Meanwhile, the Singapore Urological Association here has submitted
guidelines on Viagra to the Health Ministry for circulation to general
practitioners, said Dr Christopher Cheng, urologist at the Singapore
General Hospital.

The guidelines advise doctors on the correct use of the drug. For
instance, it gives a checklist of conditions which are not suitable for
Viagra use.

These include heart patients on nitrates and those with serious heart
problem.

straitstimes.asia1.com.sg