To: BDR who wrote (14059 ) 9/30/1998 2:14:00 AM From: BDR Read Replies (3) | Respond to of 18691
HEPH- website (http://www.holliseden.com/) is operational (wear hip boots) "The cellular energy regulator HE2000 is Hollis-Eden'spatented analogue of a human molecule that has been shown to inhibit energy-producing enzymes and other cellular proteins that are necessary for retroviral replication. The company recently completed pre-clinical testing for HE2000. When tested in vitro against strains of HIV that had developed resistance to all current combination therapies, HE2000 showed significant inhibition of viral replication and a ten-fold increase in potency over the company's native drug candidate that was previously tested in human clinical trials. This clinical plan is supported by both in vitro and in vivo studies. In one clinical study conducted with the company's native drug candidate for cellular energy regulation, multiple HIV/AIDS patients were treated at Twelve Oaks Hospital in Houston, Texas. Preliminary findings revealed no observable toxicity and no adverse side effects. In addition, the trial in Houston demonstrated that, when the company's native drug candidate was used as a monotherapy, clinically and statistically significant reductions in viral load were seen in HIV-infected patients with CD-4 counts between 50 and 300 cells/mm3. In the United States, Hollis-Eden Pharmaceuticals intends to file an IND for HE2000 to initiate Phase I / II clinical trials in the fourth quarter ." A search of the IBM Patent Search sitepatents.ibm.com yielded only this:patents.ibm.com In February, 1997, Inactivin was DHEA. In February, 1998, Inactivin became PPB2. PPB2 is now, I believe HE2000. Gotta keep up with these guys. The Houston trial referred to at the website using the "company's native drug cabdidate" utilized DHEA. Reminder: DHEA is a generic, non-patentable, "nutritional supplement". I don't believe that any of the results of the many trials referred to at the website have been published in peer reviewed journals. References are sorely lacking at the website. I am short HEPH.