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Biotech / Medical : SIBIA Neurosciences (SIBI) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (237)	10/12/1998 10:57:00 PM
From: Miljenko Zuanic	Read Replies (1) \| Respond to of 579

Rick: uspto web site is much reliable than ibm: patents.uspto.gov I go to ibm when my interest is toward specific claims or whole patent. For instance, pats # 5,804,560 and 5,714,471 are worth further reading. 5,804,560 claims: 13. A compound of claim 1 that is (2S)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide. 14. A compound of claim 1 that is (2R)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide. 15. A compound of claim 1, wherein X is selected from the group consisting of aldehyde, .alpha.-ketoester and .alpha.-ketoamide. 16. A compound of claim 1, wherein X is an aldehyde. 17. A compound of claim 6, wherein X is an aldehyde. 18. A compound of claim 6, wherein R1, R2, R3, R4, R8, RA and RB are selected such that the alkyl groups are (C1-6) alkyl, the alkenyl groups are C2-10 alkenyl and the alkynyl groups are C2-6 alkynyl. 19. A compound of claim 1 that is selected from the group consisting of (2S)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide, (2R)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide, (2R)-N-[(2R)-[2-(1'-phenyl-1'-propene)-4-methylpentanoyl)]-L-Leu-N-[2-(4-methyl-4-pentanal)]amide and (2S)-N-[(2R)-[2-(1'-phenyl-1'-propene)-4-methylpentanoyl]]-L-Leu-N-[2-(4-methyl-4-pentenal)]amide. 20. A compound of claim 1 that is selected from the group consisting of (2S)-N-[(2S)-2-benzoxy-4-methylpentanoyl ]-L-Leu-[2-(4-methyl-4-pentenal)]amide and (2R)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide. 21. A mixture of diastereomers, comprising (2SR)-N-[(2S)-2-benzoxy-4-methylpentanoyl]-L-Leu-[2-(4-methyl-4-pentenal)]amide. Significant improvement in chemistry from SIB-1508Y. btw, thanks for reply on MLNM/GLFD/NRGN issue raised in my post on BVF board. Miljenko