To: yosi s who wrote (1461 ) 10/24/1998 2:40:00 PM From: Ariella Read Replies (1) | Respond to of 1491
All you doctors put your thinking caps on:sciweb.com Describes patent granted to PHarmos in May for a part of the business we usually don't speak about. _______________________ Patent Number 5750142 Issue Date 1998 05 12 Assignee Pharmos Corp Investors Friendman, Doron; Aldouby,Yanir Title Dry compositions for preparing submicron emulsions Abstract The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component of an oil, about 0.1 to 5 weight percent of a second component of an emulsifier, about 0.25 to 25 weight percent of a cryoprotectant of an amino compound, such as one or more amino acids, peptides or protein hydrolysates, and an aqueous component, wherein the amino compound is present in an amount that is equal to or greater than that of the first component. Optionally, a co-emulsifier, a suspension agent, a preservative, an antioxidant and a drug can be added to these emulsions. Thereafter, the emulsion is lyophilized to form dry compositions that have from about 40 to about 90 weight percent of the amino compound; from about 0.1 to about 20 weight percent of the emulsifier; and from about 0.2 to about 40 weight percent of the oily component. By combining the dry composition with an appropriate quantity of an aqueous liquid, the composition is reformed as an oil-in-water emulsion. Exmp. Claim 1 Ex Claim text A lyophilized composition comprising: from about 0.2 to about 40 weight percent of an oil; from about 40 to about 90 weight percent of a cryoprotectant, wherein said cryoprotectant comprises an amino compound and is present in an amount that is equal to or greater than the amount of said oil; and from about 0.1 to about 20 weight percent of an emulsifier; the components being present in combination such that, when combined with an appropriate quantity of an aqueous liquid, the composition forms an oil-in-water emulsion; wherein the amino compound is selected from the group consisting of a straight amino acid, a branched amino acid, a nontoxic salt of a straight amino acid, a nontoxic salt of a branched amino acid, an ester of a straight amino acid, an ester of a branched amino acid, a peptide, and a protein hydrolysate.