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Biotech / Medical : Paracelsian Inc (PRLN) -- Ignore unavailable to you. Want to Upgrade?

To: joe inti who wrote (3970)	11/3/1998 12:50:00 PM
From: Robert Perissi	Read Replies (1) \| Respond to of 4342

Hello all, I saw this story today and thought it was at least slightly relevant to PRLN. The only thing I know about this is from this story, but I found the "The drug sabotages HIV's machinery.." interesting. -Why not: Go PRLN! -Rob NEW YORK (Nov. 3) - An experimental drug cut the level of the AIDS virus in patients' blood by as much as 99 percent in two weeks, according to the preliminary results of a study. That is as potent as currently approved drugs, which can drive the virus down to undetectable levels when taken longer. The experimental drug, called T-20, showed the 99-percent reductions in the four patients who took the highest dose. The drug sabotages HIV's machinery for penetrating into the body's cells, a different strategy from that used in approved HIV medications. Unlike the standard medications, T-20 wouldn't work as a pill, and was given by injection to the 16 patients in the two-week study. Results are reported in the November issue of the journal Nature Medicine by scientists at the University of Alabama at Birmingham, the drug company Trimeris Inc. of Durham, N.C., and elsewhere. Trimeris is developing T-20. In an accompanying editorial, Dr. Douglas Richman of the University of California, San Diego, cautioned that much more study will be needed to assess how useful T-20 might be. Scientists will have to investigate side effects when T-20 is taken long-term, as well as the possibility that HIV will become resistant to the drug, he wrote. AP-NY-11-03-98 0832EST