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Biotech / Medical : Ionis Pharmaceuticals (IONS) -- Ignore unavailable to you. Want to Upgrade?

To: nigel bates who wrote (2335)11/4/1998 7:23:00 PM
From: jackie  Respond to of 4676
 
nigel,

Excellent observation. My first inclination was to say let's shut 'em all down, good, bad, or indifferent.

But you can't play around with the stem cells.

My favorite cell is the pluripotent hematopoietic stem cell. This amazing creation can rebuild an entire blood system for an animal within 30 days; in one case starting out with a single cell (in a mouse.) The real problem one has in administering antineoplastics, chemotherapy, for a leukemia is the devastation of the stem cells in the bone marrow. Within 10 to 12 days all of your thrombocytes have died, leucocytes within a few days, erythrocytes within 100 to 120 days.

Biggest problem is the potential for bleeding to death because the thrombocytes are gone.

One strategy you make implement if MAG is indiscriminately stomped by your medicine is to do the same you do with chemo; give a bone marrow transplant. But what about the other stem cells in the body?

So let's hope the MAG gene is not part of the normal stem cell inventory.

Jack



To: nigel bates who wrote (2335)11/4/1998 7:35:00 PM
From: David Bogdanoff  Read Replies (1) | Respond to of 4676
 
N;

Sorry, I don't understand your response. My point is that simply observing a high frequency of cancer cells(in colon cells etc.) with MAG genes is not significant in itself. You need to observe a low frequency of normal cells(in cells of the same type) to conclude that there might be a connection between the presence of a MAG gene and cancer. Of course, that's very simplified, but you get the idea.

David


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