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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert S. who wrote (7700)	11/10/1998 1:11:00 PM
From: Tharos	Read Replies (1) \| Respond to of 17367

Not related to Xoma: Words of wisdom: Drink 'til she's cute, but stop before the wedding Eagles may soar, but weasels don't get sucked into jet engines Early bird gets the worm, but the second mouse gets the cheese I almost had a psychic girlfriend but she left me before we met I intend to live forever - so far, so good I love defenseless animals, especially in a good gravy I have a Mind Like A Steel Trap - Rusty And Illegal In 37 States The only substitute for good manners is fast reflexes Beauty is in the eye of the beer holder ... 24 hours in a day ... 24 beers in a case ... coincidence? Many people quit looking for work when they find a job Everyone has a photographic memory. Some don't have film. If you choke a smurf, what color does it turn? Who is General Failure and why is he reading my hard disk? What happens if you get scared half to death twice? I couldn't repair your brakes, so I made your horn louder. Shin: a device for finding furniture in the dark. Join the Army, meet interesting people, kill them. Why do psychics have to ask you for your name? For Sale: Parachute. Only used once, never opened, small stain. OK, so what's the speed of dark? Corduroy pillows: They're making headlines! Black holes are where God divided by zero. All those who believe in psychokinesis raise my hand.

To: Robert S. who wrote (7700)	11/12/1998 8:45:00 PM
From: Robert S.	Read Replies (1) \| Respond to of 17367

While BPI may very well prove beneficial for some indications, the synopsis below illustrates why I am skeptical of some of the claims made by posters on this board: Why may antibiotic therapy not be effective in resolving late stages of sepsis syndrome? Use of antibiotic therapy implies that the instigator of the septic cascade, a microorganism, continues to mediate progression of the disease state. If the patient is in the late stages of sepsis syndrome, e.g., multiple organ dysfunction syndrome, this may not necessarily be the case. Infection by the microorganism may have been resolved by the patient's immune system. The pathogenesis of sepsis syndrome is a complex cascade of events that involves many mediators. The factor instigating the cascade may be the release of endotoxin into the circulation from gram-negative bacteria or a comparable, cell-wall substance from gram-positive bacteria or fungi. Progression of the cascade may then be mediated by stimulation of non-specific and specific immune system components, such as cytokines (tumor necrosis factor, the interleukins, platelet activating factor), eicosanoids, complement components, and/or kinins. Once the cascade begins, the clinical progression of disease can eventually become self-perpetuating, independent of the original inflammatory trigger and/or mediators generated. Therefore, treatment targeting a specific mediator, e.g., antibiotics or antibodies to TNF, is only effective if that mediator still plays an active role in the progression of the patient's clinical condition. Antimicrobial agents are most beneficial in treating the early clinical stages of sepsis syndrome, before host factor mediators have had the opportunity to cause further progression down the septic cascade. Source: Sundaresan R, Sheagren JN: Current understanding and treatment of sepsis. Infect Med 12(6):21-268, 274, 1995. Tod