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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Bluegreen who wrote (7701)	11/10/1998 12:41:00 PM
From: aknahow	Respond to of 17367

FYI. Is this typical? From: a mother who lost her daughter to meningitis at age 20 email: wilburr@alaska.net Date: 11/5/98 Time: 1:23:37 AM Remote Name: 206.149.122.206 Comments On 4/29/98 my daughter called me in Alaska from Mesa, Arizona to tell me she wasn't feeling well. she had a bad headache and a fever of 102.5 and a sore neck.....she had been complaining of these symptoms before , about every couple of months, so she thought she had the flu again... On 4/30/98 at about 9:00am Alaska time she cslled me basck and told me she was so sick,so scared and hurt so bad all over...that she'd had diareha and vomiting since about 4:00 am Arizona time...that she'd gotten up to go to the bathroom and passed out and soiled herself and broke things in the bathroom..her friends little girl found her on the floor... she told the little girl to get her mother and my daughters friend helped her into the tub to clean up and back to bed..the friend took her little girl to a sitter... I told Krystall(my daughter) to call an ambulance..she said she couldn't afford it ...I told her to make sure she had a spinal tap...because I knew she had meningitis... I then called her sister at her fathers hoime in Mesa.. telling her to go take Krystall to the hospital...Krystall arrived at the hospital... her father met her there and with the help of Angela's husband to be got Krystall into the emergency room... the time was 11:06am... she was triaged... pulse 144..temp 98.1...blood pressure 98/57...grey/pale full of pain...put on IVs..6 IVs in less than 6 hiurs pain killers... she was so cold... hands and feet...bluish...a few bruises... head felt heavy... no record of output of urine crying from pain... couldn't walk...hurt to move...diagnosis...viral gasternitis... my ex-husband asked the doctors to check her for meningitis.. the doctors said no symptoms,they'd do a blood culture... but no spinal tap was necessary... we asked again later to check her for meningitis... again refused...the day went on ... no antibotics... medibolic acidious in her blood... the day went on...at 6:00 pm they put her in a privte room... her sister left her at 8:45pm...doctors said she'd be going home on 5/1/98...I tried to call her at 9:00pm her time... phone didn't work acording to the nurse...called back 9:25pm...nurse answered... couldn't wake her I was leaving on the plane at 12:45am alaska time to start our long awaited vacation....11:40pm alaska time ...the phone rang.. it was Angela's husband to be.. Krystall was dead.....5/2/98 the blood culture grew nesseria meninigitis... but the dr. said she had no signs..Her mother..myself was right!!! those dr.s sentienced my daughter to death...because they didn't do a simple spinal tap when asked by the family...you may wonder why we asked.. my ex-husbands cousin had it when she was little.... our family knew the signs... Krystall had just turned 20 on 2/28/98......Krystall is deeply missed by many!!!!!!

To: Bluegreen who wrote (7701)	11/10/1998 12:59:00 PM
From: aknahow	Respond to of 17367

nejm.org

To: Bluegreen who wrote (7701)	11/10/1998 5:15:00 PM
From: aknahow	Respond to of 17367

Back in 1994 there was concern about providing quick and proper attention during transport of children to hospitals. Britto J, Nadel S, Habibi P, Levin M. Pediatric risk of mortality score underestimates the requirement for intensive care during interhospital transport. Crit Care Med 1994; 22: 202930(c) Britto J, Nadel S, Habibi P, Levin M. Adverse events occurring during interhospital transfer of the critically ill. Arch Dis Child 1994; 71: 559(c)

To: Bluegreen who wrote (7701)	11/11/1998 11:52:00 AM
From: aknahow	Respond to of 17367

New page added to CF web site. The creator of this site is not endorsing any of the new treatments mentioned on this page. XOMA is mentioned only because it also has been involved in Phase I trials for CF. None of us know if these trials or BPI will be successful in the treatment of CF. www3.nbnet.nb.ca New meds for CF being studied CPX Discovered by researchers at the National Institutes of Health, CPX is being developed by SciClone Pharmaceuticals Inc. in conjunction with the Cystic Fibrosis Foundation. Being studied at 5 major CF centers in the US. Targets the defective gene causing the disease. It should alter what the defective gene does, without altering the gene itself. Phase 1 trials have just finished. Phase 1 was to monitor the safety of the drug. Phase 2 started in the Fall of 1998. Phase 2 will begin to measure whether the drug is effective. CFF's site on this study (Added Nov. 10, 1998) Phase 3 will come later on. If it passes Phase 3, it can be submitted for approval to the Food and Drug Administration. PA-1420 (polymyxin E1) Pathogenesis has been granted a US Patent for it. It's a broad-spectrum gram-negative aerosolized antibiotic now in preclinical development. It will be used to treat a number of chronic lung infections, including those common in CF, bronchiectasis, ventilator-dependant and immuno-compromised patients. Gene Therapy Glutathione Phenylbutyrate CFF's page on the Phase 1 part of this study (Added Nov. 10, 1998) Duramycin CFF's page on the Phase 1 part of this study (Added Nov. 10, 1998) tobramycin Administered IV to target a mutation in the gene that affects 3% of patients with CF. Not being used as an antibiotic for the symptoms of CF, but for it's possible usefulness as a gene-assist therapy for this specific class of mutations. This is being done at Emory University Egleston Cystic Fibrosis Center in Atlanta, Georgia. Neuprex by XOMA (can kill some gram-negative bacteria and may also make them more susceptible to antibiotics): Phase I study, in cooperation with the CFF (Added Nov. 10, 1998) Back to my CF Page

To: Bluegreen who wrote (7701)	11/11/1998 12:59:00 PM
From: aknahow	Read Replies (1) \| Respond to of 17367

As you probably know the accruals in early Nov. for Meningo were 286 and for Trauma a bit above 440. A very simplistic trend line for Trauma makes me think that at this rate the 1,600 should be reached by Jan of the year 2,000. If there are any changes in the trend up or down I will try to post my thoughts on this subject. I beg anyone that can get info off the new U.K. site to please do so. The pages show that the documents are empty, except for two that freeze my screen. got a faster modem and now these pages freeze up much more quickly. Got an adobe reader but now am afraid to download some of the FDA dockets I thought I wanted to read. They take so long, I wonder what is going to happen if I continue the download so I chicken out and press cancel. BTW European approval could come sooner, or at the same time or later than U.S. approval. I doubt anything will be presented to these regulatory bodies before the data goes to the FDA. I would hope they can at least submit it to all at the same time.