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Biotech / Medical : Ionis Pharmaceuticals (IONS) -- Ignore unavailable to you. Want to Upgrade?

To: Peter Campbell who wrote (2377)	11/15/1998 11:37:00 PM
From: jackie	Read Replies (1) \| Respond to of 4676

Peter, What I was looking for was a simple reference to a peer reviewed article demonstrating the relationship between HIV and AIDS. I know AIDS is bad. I lost a good coworker to AIDS. I appreciate your concerns regarding the effects of this terrible disease. If you had been treating syphilis patients a century ago, you would have probably recommended the administration of mercury to the unfortunates suffering from that disease. You would have no doubt have justified your clinical response with many of the statements you have made to me regarding the treatment of AIDS with AZT, etc. And you would have been wrong. Mercury would have cause more harm than good. Yet, this was the only response medical science had at the time. Can we get back to the basics of my original query? What proof do we have AIDS is caused by HIV? Rather than take up everyone's time on this thread with this obviously emotional issue, I thought it would be a good idea to start another thread devoted to this and other controversial issues. Subject 23709 Let's have it out there Peter, and leave the Isis folks alone. By the way, I hope my fox doesn't find out about it's involvement in mere human controversies regarding our health and welfare. I'm sure I'm much more of threat to him than he will ever be to me. Also by the way, rabies meets all the criteria of Koch's rules. Unlike HIV. Regards, Jack Simmons

To: Peter Campbell who wrote (2377)	11/17/1998 3:36:00 AM
From: SnowShredder	Respond to of 4676

filling the cell and bursting out in masses I assume you are talking about viral replication...isn't HIV a lentivirus...thus it does not fill with completely packaged virions... burst the cell releasing its progeny all @ once (which would be more like an adenovirus)...but rather buds off its progeny as they are produced...Although I view the CD4 cell death as an effect of the natural budding off lifecycle (non lytic as a retrovirus)...: CD4 cells do not usually survive invasion by HIV. Either they disintegrate because of the large number of viruses budding off, or the body's immune system will recognise the viral envelope proteins in the cell membrane and destroy the damaged cells. roche-hiv.com Best of Luck, Where'd He Go?