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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert S. who wrote (7779)	11/20/1998 7:57:00 AM
From: Robert K.	Read Replies (1) \| Respond to of 17367

There is no contradiction between MY statements. I stand by what I said. As I understand it there is no neutralization as that abstract states. I believe (IMO) that attenuation is the correct description. The article below calls it suppression or inhibition. You decide. You are obviously drawing questions from the abstracts you are reading. So how about you answer those questions I put forth to you now that I have put forth this info. As always all IMO all disclaimers. > J Immunol 1997 Nov 15;159(10):5079-83 Two functionally independent pathways for lipopolysaccharide-dependent activation of mouse peritoneal macrophages. Amura CR, Chen LC, Hirohashi N, Lei MG, Morrison DC Department of Microbiology, Molecular Genetics, and Immunology, The University of Kansas Medical Center, Kansas City 66160, USA. We have investigated the effects of human LPS-binding protein (LBP) and human bactericidal/permeability-increasing protein (BPI) on LPS-dependent activation of mouse thioglycolate-elicited peritoneal macrophages in vitro, in comparison with human PBMCs. Confirming earlier published studies, BPI inhibited, and LBP enhanced, the ability of LPS to stimulate PBMC production of the cytokines TNF-alpha and IL-6. In marked contrast to these results, under identical conditions of in vitro culture, both LBP and BPI suppressed, in a dose-dependent manner, the ability of LPS to stimulate cytokine production in mouse macrophages. Further, while human BPI also suppressed LPS-dependent NO secretion in mouse macrophages, human LBP had no inhibitory effect on NO secretion under conditions that inhibited TNF-alpha secretion. These data provide the first direct evidence that mouse macrophages may utilize two independent pathways in response to LPS, thus leading to different phenotypic responses