To: J. Nelson who wrote (46 ) 12/15/1998 3:07:00 PM From: MoneyMade Read Replies (3) | Respond to of 15987
VRTX---Tuesday December 15, 2:08 pm Eastern Time Vertex says some tumors shrink in cancer study CAMBRIDGE, Mass., Dec 15 (Reuters) - Vertex Pharmaceuticals Inc. (Nasdaq:VRTX - news) said Tuesday that preliminary results of a Phase II trial show that tumors in some patients with advanced breast cancer shrank when the standard paclitaxel treatment was combined with the Vertex drug Incel. Vertex said that of 32 patients, a partial response (50 percent or more tumor regression) was noted in three patients, and a minor response (25 to 50 percent regression) was noted in one patient. Of these four patients, three had experienced tumor growth during a previous course of paclitaxel therapy. The study is part of a broad program evaluating Incel's potential to resensitize drug-resistant tumors to chemotherapy in a range of cancer types and therapeutic regimens. Vertex said treatment with Incel and paclitaxel has been well tolerated. With Incel coadministration, only half the standard dose of paclitaxel is necessary to achieve and maintain paclitaxel blood levels comparable to those produced using the higher usual dose of paclitaxel alone, it said. ''The potential of Incel to enhance or restore a therapeutic effect of paclitaxel is a promising finding from this exploratory study and provides justification for future trials in patients with less advanced disease,'' George Demetri of Dana-Farber Cancer Institute, principal investigator for the study, said in a press release. Enrollment in the breast cancer study will be completed early next year with 40 to 50 patients. The company said additional Phase II clinical results from Incel trials in other tumors, which it expects to be available in 1999, will help the company select the most appropriate regimens and indications for Phase III clinical development. Vertex said the Phase II clinical trial data were reported today at the 21st annual Breast Cancer Symposium in San Antonio, Texas.