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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Bluegreen who wrote (7803)	11/24/1998 12:53:00 PM
From: aknahow	Respond to of 17367

Interest in LBP? Scripps assigned a patent last week. United States Patent 5,837,810 Han , et al. November 17, 1998 Polypeptides of lipopolysaccharide binding protein Abstract The present invention provides a first polypeptide fragment of lipopolysaccharide (LPS) binding protein (LBP) which binds to lipopolysaccharide, but prevents the LPS:LBP complex from either transferring LPS to CD14 or promoting the formation of an LPS:CD14 complex and a second polypeptide fragment of LBP which binds to CD14 receptor to inhibit binding of LPS:LBP complex to the CD14 receptor. Also included are methods of ameliorating symptoms of sepsis in a subject by administration of a LBP polypeptide of the invention, or administration of antibody to LBP polypeptide or anti-idiotype antibody. Inventors: Han; Jiahuai (La Jolla, CA); Ulevitch; Richard J. (Del Mar, CA); Tobias; Peter S. (San Diego, CA) Assignee: The Scripps Research Institute (La Jolla, CA) Appl. No.: 215089 Filed: March 15, 1994 U.S. Class: 530/350 Intern'l Class: C07K 014/47 Field of Search: 530/350