To: Anthony Wong who wrote (6337 ) 11/24/1998 5:41:00 PM From: Anthony Wong Respond to of 9523
Pfizer's Zoloft Effective for Obsessive-Compulsive Kids Bloomberg News November 24, 1998, 4:47 p.m. ET Pfizer's Zoloft Effective for Obsessive-Compulsive Kids Chicago, Nov. 24 (Bloomberg) -- Pfizer Inc.'s depression drug Zoloft is a safe and effective treatment for children with obsessive-compulsive disorder, a new study shows. Although the drug is widely used for adults with obsessive- compulsive disorder, known as OCD, this is the first large clinical trial in children and adolescents. OCD affects about one in 200 children, causing persistent and irrational worries that trigger repetitive behavior like hand washing to alleviate the concerns. Dr. John S. March from Duke University Medical Center in Durham, North Carolina, and his colleagues gave the drug or placebo to 187 patients for 12 weeks. The superiority of Zoloft was seen for most patients at about the third week of treatment, with 42 percent on the drug ''very much or much improved,'' compared with 26 percent on placebo. The average patient remained mildly ill even after taking Zoloft, the researchers said, recommending a combination of drug therapy and psychotherapy for children with the disease. Side effects, including insomnia, nausea, agitation and tremor, also were significantly more common among treated patients. ''Although current treatments are not generally curative, given a correct diagnosis and skillful treatment most children and adolescents with OCD will improve considerably,'' they said. The study, sponsored by New York-based Pfizer, appears in tomorrow's Journal of the American Medical Association. The U.S. Food and Drug Administration is pushing pharmaceutical companies to test products in children since most new drugs get to the market without conclusive proof of safety and effectiveness for younger users. Doctors nonetheless prescribe the drugs for kids because newer products often are considered superior. Eli Lilly & Co.'s Prozac, SmithKline Beecham Plc's Paxil and Forest Laboratories Inc.'s Celexa, also marketed by Warner- Lambert Co., all work in similar ways to Zoloft and together dominate the $8.4 billion worldwide market for depression drugs. --Michelle Fay Cortez in Ithaca, New York (607) 272-1174, through