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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert S. who wrote (7944)	12/4/1998 5:30:00 PM
From: Robert K.	Read Replies (3) \| Respond to of 17367

Listen, anytime you eliminiate a foreign object IMO its a plus. Since endotoxins are "toxins" IMO its a plus and is IMO beneficial to the host.. Now whether or not it works in "sepsis" remains to be seen. Sepsis is a broad disease that is basically not even definable. Yes, there is considerable controversy over "what is sepsis". So in summary, IMO, is removal of toxins benefecial to the host>yes. Is removal of toxin benefecial in sepsis? One must first define sepsis. If you define it as "endotoxin driven" sepsis, then one must say "potentially". All IMO, all disclaimers.

To: Robert S. who wrote (7944)	12/5/1998 1:11:00 AM
From: aknahow	Respond to of 17367

RobertS, when you get a chance please let these people know they are headed in the wrong direction. 6th Vienna Shock Forum STRATEGIES TO DEAL WITH GUT-ORIGIN BACTEREMIA/ENDOTOXEMIA S. Bahrami, H. Redl, G. Schlag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna Ludwig Boltzmann Inst. Exp. & Clin. Traumatology, Vienna, Austria A causal relationship between gut-origin endotoxemia/ bacteremia and septic complications, on the one hand, and clinical outcome from hemorrhage and trauma on the other is still a matter of dispute. If invading enteric bacteria and endotoxin are indeed the reason for the development of sepsis and the irreversibility of shock, then elimination of bacteria/bacterial endotoxin should improve resistance to hypovolaemic insult. In fact, anti-endotoxin measures in our experimental studies provided noticeable protection of vital organs, particularly the lung and intestine, against hemorrhage-induced injury and improved survival. Our data imply that systemic endotoxemia not only occurs early in the ischemic episode but also plays an important role in morbidity and mortality due to severe hemorrhage. Consequently, when the gut is suspected of being the source of bacteria/endotoxin causing systemic infections, the first logical step is to reduce the amount of bacteria and/or endotoxin in the gut lumen and support the mucosal barrier function to minimize the chances of bacterial translocation. Next in importance, if translocation cannot be prevented, is to kill bacteria, neutralize endotoxin, and eliminate bacteria/bacterial products that enter the extraluminal compartments. In the following presentation we will emphasize the significance of gut-origin bacteremia/endotoxemia and the possible intervention strategies for them. © ESS 1997, by H.Redl & Die Seitenmanufaktur

To: Robert S. who wrote (7944)	12/5/1998 8:45:00 AM
From: Tharos	Respond to of 17367

The hypothesis that neutralization of endotoxin and pro-inflammatory cytokines is beneficial in sepsis was seriously challenged by the results of recent clinical and experimental studies. How were the studies set up? What pharmaceuticals did they use to treat the sepsis? For all we know your source spit into a bag and administered it to two patients. Targeting a single microbial toxin such as endotoxin may not represent a viable strategy for treating a complex inflammatory response to diverse gram-negative bacteria. Makes sense. No one here ever said, "Flush out the endotoxins and blow-off the bacteria." But it is apparent, at least to me, that rBPI has some anti-bacterial properties and is synergistic when used with antibiotics. So again, what's you point? That rBPI wont be used by itself to treat complex bacterial infections with serious sepsis cascade already in place. Thanks for the news flash, Speedo, but I already knew that. You didn't have to put your head up your butt to tell me. Finally, our [read: MY] scientific knowledge of the complex timing of mediator release and balance during sepsis may be insufficient [add: FOR ME] to develop successful therapeutic interventions for this syndrome [add: AT THIS TIME]. No kidding, that's why companies are scrambling to find a cure. Say, did you know BPI is discussed in third year college biology books?