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Biotech / Medical : Merck -- Ignore unavailable to you. Want to Upgrade?


To: Patsy Collins who wrote (1085)12/9/1998 4:38:00 PM
From: Anthony Wong  Respond to of 1580
 
Patsy, see my reply to Rob. All IMHO, of course. CNBC has been saying all yesterday afternoon that Merck is probably going to say whether they've got priority review status for Vioxx in today's analyst meeting. A bit of selling on news. It (priority review status) may yet happen, you'll never know, but I guess investors are disappointed.



To: Patsy Collins who wrote (1085)12/9/1998 5:09:00 PM
From: Anthony Wong  Respond to of 1580
 
Merck Guides Analysts to Lower Estimates, Shares Fall (Update1)

Bloomberg News
December 9, 1998, 4:36 p.m. ET

Merck Guides Analysts to Lower Estimates, Shares Fall (Update1)

(Updates markets, adds analyst comment)

Whitehouse Station, New Jersey, Dec. 9 (Bloomberg) -- Merck
& Co., the world's biggest drugmaker, guided analysts to lower
estimates for its profit in 1999 as it hires new sales people
and prepares to introduce its most important new drug.

Merck Chairman and Chief Executive Raymond Gilmartin said
the company could have per-share profit of $4.27 to $4.34 in 1998
and $4.85 to $4.95 in 1999.

Gilmartin's remarks at the company's annual meeting with
analysts meeting at its headquarters in Whitehouse Station, New
Jersey, sent shares down because the figures he gave are at the
lower end of the range of analysts' estimates.

Merck had been expected to earn $4.30 a share in 1998 and
$4.97 a share in 1999, the average estimates of analysts polled
by First Call Corp.

Merck fell 6 7/16 to close at 152 1/4. Earlier in the day,
Merck touched an all time high of 161 3/4.

Overall, investors were disappointed that Merck didn't have
any dramatic good news to announce at the analysts meeting, as it
has in past years, said Jeffrey J. Kraws, an analyst with Everen
Securities with an ''outperform'' rating on Merck.

''There was a lot of pent-up demand,'' he said.

Expanded Sales Force

Earlier, Merck said it will add about 700 new sales
representatives in the U.S. next year, expanding its current
sales force of about 4,000 by 17.5 percent.

Merck, the maker of the cholesterol reducer Zocor and the
AIDS pill Crixivan, said about 600 of the new sales
representatives will target primary care physicians.

The company also said it's seeking U.S. Food and Drug
Administration permission to include information on its Zocor
drug's label about how it may help boost levels of HDL, the so-
called ''good cholesterol.''

The move shows Merck is working hard to compete against
Warner-Lambert Co.'s cholesterol-reducing drug Lipitor, said
Viren Mehta, an analyst with Mehta Partners, which has a ''buy''
on Merck.

Merck also said it is optimistic about the chances of
getting quick regulatory review of its experimental arthritis
medicine Vioxx.

If Merck wins accelerated review at the U.S. Food and Drug
Administration, Vioxx could be introduced about six months after
Celebrex. If not, it could follow by about a year.

Merck disclosed for the first time a study that indicates
Vioxx is statistically no more likely to cause stomach ulcers
than a placebo, or a sugar pill. That finding is important
because Vioxx is likely to be prescribed for long-term use in
patients suffering from arthritis, who risk developing ulcers
when they use existing painkillers.

Marketplace Battle

Merck is lagging rival Monsanto Co. in what likely will
become ''one hell of a marketplace battle,'' said Anstice, who
leads Merck's U.S. drug sales. At an analyst meeting today, Merck
said its studies of Vioxx are more extensive than was the
research Monsanto has done on its similar drug, Celebrex.

Vioxx and Monsanto's Celebrex are both so-called Cox-2
drugs, which appear to treat pain and swelling without causing
irritating the stomach as existing painkillers do.

Merck told analysts today that after three months, 7.3
percent of patients on placebo had ulcers, compared to 4.7
percent of those who received a 25 milligram daily dose of Vioxx
and 8.1 percent of those who received 50 milligrams. By
comparison, 28.5 percent of those treated with the painkiller
ibuprofen developed ulcers.

Merck submitted its FDA application for Vioxx in November.
Merck is looking to Vioxx to offset the expected loss of patent
by 2001 on four drugs with combined 1997 sales of $3.5 billion.

Vioxx and Celebrex is expected to be the first of a new
class of painkillers, the Cox-2 drugs. These appear to treat pain
and swelling without the side effects of existing painkillers,
which can cause stomach bleeding. Vioxx and Celebrex are each
expected to have annual sales of more than $1 billion.

--Kerry Dooley in Whitehouse Station through the Washington

news.com



To: Patsy Collins who wrote (1085)12/9/1998 5:28:00 PM
From: Anthony Wong  Respond to of 1580
 
DJ - Merck Says It Can Handle Challenges Ahead, Will Boost Sales Force
December 09, 1998 4:15 PM

NEW YORK -(Dow Jones)- Merck & Co. Chairman and Chief Executive
Raymond Gilmartin assured Wall Street analysts Wednesday that the
pharmaceutical giant can keep growing in the face of several upcoming
key patent expirations and an increasingly competitive environment, and
announced a huge expansion of its sales force.

"We're well-prepared to overcome these patent expirations," Gilmartin
said at the company's annual business briefing at the Whitehouse
Station, N.J., corporate headquarters.

The major drugs going off patent in 2000 and 2001 represent a significant
percentage of Merck's sales. The products include the blood pressure
drugs Vasotec and Prinivil, the cholesterol drug Mevacor, the antacid
Pepcid and the company's share of Prilosec, an ulcer drug sold through a
joint venture with Astra AB.

Merck's (MRK) president of Human Health for the Americas, David
Anstice, said the company has started a 700-person sales-force
expansion, in part to support the expected upcoming launch of Vioxx, the
company's treatment for arthritis currently in review by the Food and Drug
Administration. Analysts expect Vioxx, a member of a new class of
drugs called COX-2 inhibitors, to reach blockbuster status. COX-2
inhibitors don't cause the same gastrointestinal side effects as other pain
killers, because they spare an enzyme that protects the stomach. The
FDA recently cleared the first drug in that class, Monsanto Co.'s
Celebrex.

The company said Vioxx caused a lower rate of ulcers in osteoarthritis
patients than ibuprofen. The company also cited two acute pain studies
in which Vioxx relieved dental pain and post-orthopedic surgery pain
comparable with widely used prescription nonsteroidal anti-inflammatory
drugs and was superior to a placebo.

Of the added sales staff, 100 will work in the cardiovascular area, with a
particular focus on Zocor, Merck's cholesterol-lowering drug which has
been losing market share to Lipitor, a product co-marketed by
Warner-Lambert Co. (WLA) and Pfizer Inc. (PFE). But Anstice assured
analysts that the company is pushing Zocor hard and added, "at the
moment, our new (Zocor) prescription share is leveling."

"This (cholesterol-lowering) market really can turn into a two-horse race,"
Anstice said.

The drugs belong to a class of medicines known as statins, which can
dramatically reduce cholesterol and reduce the risks of heart attacks.

Since 1995, Merck has launched 14 medicines and vaccines that now
account for 21% of top-line sales. Five of the 14 were launched this year,
including Singulair for asthma, Maxalt for migraines, Aggrastat for
cardiovascular disorders, Propecia for baldness and Cosopt for
glaucoma.

While Wall Street has looked to the new drugs to make up for an
expected drop-off in more established products as patents expire, results
have been mixed. Sales of Singulair, a once-a-day tablet to treat chronic
asthma in adults and children, have done better than Propecia and
Maxalt. Singulair sold $55 million in the third quarter, with $41 million of
that coming from the U.S. But Propecia sales during the third quarter
were $24 million and Maxalt was $15 million.

Some analysts have voiced concern about the product launches that
have been slower than expected, but Merck said it's pleased with the
launches and argued Wednesday that it's still early in the game.

"I stress that these five new products are all at the very early stages of
their life cycles, and are not yet fully launched worldwide," Gilmartin said.
He added that Merck will continue next year to roll out these products in
the rest of the world, including key countries in Europe.

Merck's long-term goal is to achieve earnings-per-share growth within the
top quartile of its peer group, which Gilmartin defined as 12 large-cap
multinational pharmaceutical companies including the likes of Pfizer, Eli
Lilly & Co. (LLY) and Glaxo Wellcome PLC (GLX).

"The key to achieving this growth goal is to drive revenue growth," he
said.

In the short term, Gilmartin said, Merck is driving revenue growth by
increasing the promotional support of its major in-line products and
investing in the launch of its new products world-wide. The company is
funding the investment behind these two growth drivers of its business, in
part, by reallocating productivity savings in manufacturing and in its
administrative structure.

Still, Merck faces added competition amid a fast-changing competitive
landscape in the drug industry.

"Today, it is often only a few months before a competitor enters the
market with a product in the same therapeutic category, with others
quickly behind," Gilmartin said.

To fight that, Merck has in place two-part plan. The plan includes
discovering new medicines through what Gilmartin called "breakthrough
research" and demonstrating the value of the company's medicines to
physicians, payers and patients.

Copyright (c) 1998 Dow Jones & Company, Inc.

All Rights Reserved.



To: Patsy Collins who wrote (1085)12/9/1998 6:09:00 PM
From: Anthony Wong  Read Replies (1) | Respond to of 1580
 
DJ - Merck Shares Slide As Company Trims Earnings Outlook For '99
December 09, 1998 5:22 PM

NEW YORK -(Dow Jones)- Shares of Merck & Co. sank late Wednesday
after the company's chairman indicated earnings next year are likely to
fall slightly short of Wall Street estimates.

Chairman and Chief Executive Raymond Gilmartin said he is comfortable
with 1998 net income estimates of $4.27 to $4.34 a diluted share, which
would be in line with estimates. However, he also said 1999 earnings
estimates of $4.85 to $4.95 a share are "reasonable." That range is
below the First Call mean analysts' estimate of $4.97 a share.

Merck shares (MRK) ended down $6.75, or 4.3%, at $151.938, with most
of the decline coming in the last minutes of trading after the earnings
estimate was reported.

Gilmartin and other Merck executives addressed the investment
community Wednesday at the company's annual business briefing in
Whitehouse Station, N.J.

In other comments, Gilmartin said Merck plans to invest $2.1 billion on
research and development in 1999, a 14% increase from 1998. He
assured Wall Street analysts that the pharmaceutical giant can keep
growing in the face of several upcoming key patent expirations and an
increasingly competitive environment, and announced a huge expansion
of its sales force.

"We're well-prepared to overcome these patent expirations," Gilmartin
said at the company's annual business briefing at the Whitehouse
Station, N.J., corporate headquarters.

The major drugs going off patent in 2000 and 2001 represent a significant
percentage of Merck's sales. The products include the blood pressure
drugs Vasotec and Prinivil, the cholesterol drug Mevacor, the antacid
Pepcid and the company's share of Prilosec, an ulcer drug sold through a
joint venture with Astra AB.

Merck's (MRK) president of Human Health for the Americas, David
Anstice, said the company has started a 700-person sales-force
expansion, in part to support the expected upcoming launch of Vioxx, the
company's treatment for arthritis currently in review by the Food and Drug
Administration. Analysts expect Vioxx, a member of a new class of
drugs called COX-2 inhibitors, to reach blockbuster status. COX-2
inhibitors don't cause the same gastrointestinal side effects as other pain
killers, because they spare an enzyme that protects the stomach. The
FDA recently cleared the first drug in that class, Monsanto Co.'s
Celebrex.

The company said Vioxx caused a lower rate of ulcers in osteoarthritis
patients than ibuprofen. The company also cited two acute pain studies
in which Vioxx relieved dental pain and post-orthopedic surgery pain
comparable with widely used prescription nonsteroidal anti-inflammatory
drugs and was superior to a placebo.

Of the added sales staff, 100 will work in the cardiovascular area, with a
particular focus on Zocor, Merck's cholesterol-lowering drug which has
been losing market share to Lipitor, a product co-marketed by
Warner-Lambert Co. (WLA) and Pfizer Inc. (PFE). But Anstice assured
analysts that the company is pushing Zocor hard and added, "at the
moment, our new (Zocor) prescription share is leveling."

"This (cholesterol-lowering) market really can turn into a two-horse race,"
Anstice said.

The drugs belong to a class of medicines known as statins, which can
dramatically reduce cholesterol and reduce the risks of heart attacks.

Since 1995, Merck has launched 14 medicines and vaccines that now
account for 21% of top-line sales. Five of the 14 were launched this year,
including Singulair for asthma, Maxalt for migraines, Aggrastat for
cardiovascular disorders, Propecia for baldness and Cosopt for
glaucoma.

While Wall Street has looked to the new drugs to make up for an
expected drop-off in more established products as patents expire, results
have been mixed. Sales of Singulair, a once-a-day tablet to treat chronic
asthma in adults and children, have done better than Propecia and
Maxalt. Singulair sold $55 million in the third quarter, with $41 million of
that coming from the U.S. But Propecia sales during the third quarter
were $24 million and Maxalt was $15 million.

Some analysts have voiced concern about the product launches that
have been slower than expected, but Merck said it's pleased with the
launches and argued Wednesday that it's still early in the game.

"I stress that these five new products are all at the very early stages of
their life cycles, and are not yet fully launched worldwide," Gilmartin said.
He added that Merck will continue next year to roll out these products in
the rest of the world, including key countries in Europe.

Merck's long-term goal is to achieve earnings-per-share growth within the
top quartile of its peer group, which Gilmartin defined as 12 large-cap
multinational pharmaceutical companies including the likes of Pfizer, Eli
Lilly & Co. (LLY) and Glaxo Wellcome PLC (GLX).

"The key to achieving this growth goal is to drive revenue growth," he
said.

In the short term, Gilmartin said, Merck is driving revenue growth by
increasing the promotional support of its major in-line products and
investing in the launch of its new products world-wide. The company is
funding the investment behind these two growth drivers of its business, in
part, by reallocating productivity savings in manufacturing and in its
administrative structure.

Still, Merck faces added competition amid a fast-changing competitive
landscape in the drug industry.

"Today, it is often only a few months before a competitor enters the
market with a product in the same therapeutic category, with others
quickly behind," Gilmartin said.

To fight that, Merck has in place two-part plan. The plan includes
discovering new medicines through what Gilmartin called "breakthrough
research" and demonstrating the value of the company's medicines to
physicians, payers and patients.

Meanwhile, Chief Financial Officer Judy Lewent said the $30 billion
merger between and Zeneca Group PLC (ZEN), confirmed Tuesday, will
generate a payment of $675 million to $1 billion to Merck from Astra upon
the closing of the transaction.

Merck earlier this year restructured its Astra Merck joint venture, a move
Gilmartin said "has the potential to enhance the already favorable
financial performance of that relationship."

Copyright (c) 1998 Dow Jones & Company, Inc.

All Rights Reserved.