To: Robert K. who wrote (8008 ) 12/11/1998 11:30:00 PM From: aknahow Read Replies (2) | Respond to of 17367
PDF Pretty Damn Funny. Found it, but can't read it. Sorry I still don't know how to make it work, even after loading the Adobe Reader. Go to the prior post where link to Journal is. Then go to 1998 and you will see months listed 12,11,10 etc. issue number is in front. Long explanation because. Well Bob, just because.... European Journal of Pediatrics ISSN: 0340-6199 (printed version) ISSN: 1432-1076 (electronic version) Table of Contents Abstract Volume 157 Issue 11 (1998) pp 869-880 review: Pathophysiology of meningococcal sepsis in children E. D. de Kleijn, J. A. Hazelzet, R. F. Kornelisse, R. de Groot Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands, Tel.: +31-10-4636691, Fax: +31-10-4636449 Received: 9 February 1998 / Accepted in revised form: 26 May 1998 Abstract Septic shock with purpura is a syndrome frequently diagnosed in children and predominantly caused by Neisseria meningitidis. Despite improvements in management and therapy the mortality and morbidity in these patients are still high. During the last few years much effort has been put into understanding of the systemic host response during this acute infectious disease. This host response can be divided into the process of recognition of endotoxin, the cascade of pro- and counter inflammatory mediators, the endothelial damage resulting in capillary leakage and inappropriate vascular tone, and the procoagulant state. Conclusion This paper reviews the recent insights in the pathophysiology of the host response and their possible consequences for novel therapies in meningococcal sepsis. Key words Meningococcal infection · Sepsis · Children · Pathophysiology · Treatment Article in PDF format (297 KB) Online publication: October 27, 1998 LINK Helpdesk © Springer-Verlag Berlin Heidelberg 1998